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A formula of an antimicrobial oil emulsion microcapsule for veterinary use

A technology of antibacterial drugs and oil emulsions, which is applied in the direction of antibacterial drugs, pharmaceutical formulas, microcapsules, etc., can solve the problems of long-term tissue residues and inconvenient operation of oil emulsion administration, and achieve low cost, convenient clinical application, and emulsion-through-acupuncture good sex effect

Inactive Publication Date: 2013-04-24
HUNAN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inconvenient administration of oil emulsions and the long-term residue in local tissues of the body have become the bottleneck of the popularization and application of long-acting oil emulsions.

Method used

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  • A formula of an antimicrobial oil emulsion microcapsule for veterinary use
  • A formula of an antimicrobial oil emulsion microcapsule for veterinary use
  • A formula of an antimicrobial oil emulsion microcapsule for veterinary use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Preparation of 20% Florfenicol Emulsion Microcapsules, Antibacterial Effect in Vitro and Clinical Application

[0022] formula:

[0023] Florfenicol 80g

[0024] Oil for injection 300ml

[0025] Span-80 10ml

[0026] Tween-80 5ml

[0027] Water for injection 250ml

[0028] PEG8000 1.0g

[0029] Soluble starch 250g

[0030] Methylcellulose 50g

[0031] The oil emulsion microcapsule coating agent contains veterinary antibacterial drug oil emulsion, the oil emulsion is in the state of powder microcapsule particles, and the animal absorbs the emulsion when it is fed to the animal, and the antibacterial drug in the emulsion is released step by step in the animal body, forming Sustained release effect. Moreover, plant active ingredient extracts or monomers that can improve the body's immunity can be added to Florfenicol, including astragalus polysaccharide extract, isatis root extract, rhubarb extract, berberine, sanguinarine, and chelidonine Plant monomers, so the e...

Embodiment 2

[0067] The preparation formula of 10% compound enrofloxacin microcapsules is:

[0068] Enrofloxacin 100g

[0069] Oil for injection 250ml

[0070] Span-80 5ml

[0071] Tween-80 10ml

[0072] Water for injection 350ml

[0073] PEG8000 1.0g

[0074] Powder Soluble 350g

[0075] Methylcellulose 80g

[0076] The oil emulsion microcapsule coating agent contains veterinary antibacterial drug oil emulsion, the oil emulsion is in the state of powder microcapsule particles, and the animal absorbs the emulsion when it is fed to the animal, and the antibacterial drug in the emulsion is released step by step in the animal body, forming Sustained release effect. In addition, enrofloxacin can be added to enrofloxacin to add plant active ingredient extracts or monomers that can improve the body's immunity, including astragalus polysaccharide extract, isatis root extract, rhubarb extract, berberine, sanguinarine, chelidonine Plant monomers, so the effect is better. The oil for inject...

Embodiment 3

[0112] 10% Sulfamethoxine microcapsules

[0113] The formula is:

[0114] Sulfamethoxine 80g

[0115] Oil for injection 500ml

[0116] Span-80 8ml

[0117] Tween-80 8ml

[0118] Water for injection 250ml

[0119] PEG8000 1.0g

[0120] Soluble starch 500g

[0121] Methylcellulose 100g

[0122] The oil emulsion microcapsule coating agent contains veterinary antibacterial drug oil emulsion, the oil emulsion is in the state of powder microcapsule particles, and the animal absorbs the emulsion when it is fed to the animal, and the antibacterial drug in the emulsion is released step by step in the animal body, forming Sustained release effect. In addition, sulfamethoxine can be added with plant active ingredient extracts or monomers that can improve the body's immunity, including astragalus polysaccharide extract, isatis root extract, rhubarb extract, berberine, sanguinarine, and chelidonine Plant monomers, so the effect is better. The oil for injection can be any one of s...

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Abstract

The invention discloses a formula of an antimicrobial oil emulsion microcapsule for veterinary use, wherein per 1000g of the antimicrobial oil emulsion microcapsule contains 50-100g of an antimicrobial agent, 250-500ml of oil for injection, 250-500ml of water for injection, 1-5g of PEG, 5-10ml of sorbitan fatty acid ester, 5-10ml of polyoxyethylene sorbitan fatty acid ester, 250-500g of soluble starch, and 50-100g of methyl cellulose. According to the present invention, the oil emulsion is developed to be microcapsules which can be used for oral administration, thereby maintaining the long-acting and sustained-release effects of the oil emulsion, while in a large extent preventing disadvantages and side reactions in the production and application of the oil emulsion. The preparation process of the microcapsules is relatively simple, reducing the use of organic solvents and thereby reducing the cost of the product.

Description

technical field [0001] The present invention relates to the creation of a new dosage form of veterinary antibacterial drugs, in particular to the microcapsule coating agent of oil emulsion of veterinary antibacterial drugs, so that the oil emulsion of antibacterial drugs can be administered orally, thereby forming a new way of oral administration of long-acting preparations, The invention also relates to the preparation method and clinical application of the dosage form. Background technique [0002] At present, in the field of veterinary pharmacy, especially in the field of antibacterial pharmacy, the commonly used dosage forms are several conventional dosage forms such as powder, premix, ordinary water injection, tablet and granule. Such preparations play an important role in controlling animal diseases. played an important role. However, in recent years, animal husbandry diseases have been spreading all over the world, and a vicious cycle of mixed infections has emerged....

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K9/50A61K45/00A61K31/65A61K31/496A61K31/165A61P31/04
Inventor 董伟陈小军孙志良
Owner HUNAN AGRICULTURAL UNIV
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