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Oil composition for promoting insulin secretion

A technology for oil composition and insulin secretion, which is applied in the direction of drug combination, function and application of food ingredients, can solve the problems of islet beta cell failure, weight gain, hypoglycemia, etc., and achieves excellent insulin secretion promoting effect and safety. High, safe and unnecessary effects

Active Publication Date: 2015-11-25
THE NISSHIN OILLIO GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, SU agents can cause side effects such as islet β-cell failure, hypoglycemia, itching, rash, and weight gain.

Method used

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  • Oil composition for promoting insulin secretion
  • Oil composition for promoting insulin secretion
  • Oil composition for promoting insulin secretion

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0079] Manufacturing method of sample 1

[0080] To 10 ml of a 40% glucose (D(+)-Glucose, manufactured by Wako Pure Chemical Industries, Ltd.) solution, 2 g of LCT (trade name: Nissin Canoichira Oil, manufactured by Nissin Oiliyo Group Co., Ltd.) and bovine serum albumin ( SIGMA) 200 mg, and the obtained solution was subjected to ultrasonic treatment (5 minutes for two groups, 10 minutes in total) while cooling the obtained solution on ice, to obtain a sample 1. Table 1 shows the fatty acid composition of LCT (trade name: Nissin Canoichira Oil, manufactured by Nissin Oiliyo Group Co., Ltd.) used as a control.

[0081] [Table 1]

[0082]

manufacture example 2

[0083] Manufacturing method of sample 2

[0084] MCT (trade name: O.D.O, structural fatty acid: n-octanoic acid / n-capric acid = 3 / 1, manufactured by Nissin Oliver Group Co., Ltd.) and LCT (trade name: Nissin キヤノカラ oil, Nissin Oliver Group Co., Ltd.) was mixed at a ratio of 14:86 (mass ratio) to obtain a mixed oil. To the obtained mixed oil, lipase powder was added so that the lipase powder was 0.1% by mass based on the mixed oil, and stirred at 60° C. for 15 hours to cause a transesterification reaction. Next, the lipase powder was removed by filtration from the reaction product, and the filtrate was washed with water, dried, and decolorized and deodorized to obtain a transesterified oil (MLCT) of MCT and LCT. Then, to 10 ml of a 40% glucose (D(+)-Glucose, manufactured by Wako Pure Chemical Industries, Ltd.) solution, 2 g of the above-mentioned MLCT and an emulsifier (pentaglyceroltrioleate, trade name: Sunsoft A-173E, HLB) were added : 7, Taiyo Chemical Co., Ltd.) 20 mg an...

manufacture example 3

[0100] Manufacturing method of sample 3

[0101] To 10 ml of a 40% glucose (D(+)-Glucose, manufactured by Wako Pure Chemical Industries, Ltd.) solution, 2 g of LCT (trade name: Nissin Canoichira Oil, manufactured by Nissin Oiliyo Group Co., Ltd.), an emulsifier (5 Polyglyceryl trioleate, trade name: Sunsoft A-173E, HLB: 7, manufactured by Sun Chemical Co., Ltd.) 20 mg and bovine serum albumin (manufactured by SIGMA Co., Ltd.) 200 mg, and ultrasonication was performed while cooling the obtained solution on ice The treatment (5 minutes for two groups, 10 minutes in total) yielded sample 3.

[0102] 7-week-old male SD rats (purchased from Japan SLC Company) were used in the experiment. After the rats (17 rats) were acclimatized for one week, Sample 1 and Sample 3 were administered at the age of 8 weeks and 9 weeks, and a sugar load test was performed by the crossover method. The breeding conditions were the same as in Test Example 1.

[0103] The test was divided into two gro...

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PUM

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Abstract

Provided is an oil or fat composition for promoting insulin secretion, the composition being very safe, devoid of concerns of side effects even when ingested continuously, and effective in preventing diabetes and other uses. This oil or fat composition for promoting insulin secretion is characterized in containing a triacylglycerol and an emulsifier as active ingredients, the triacylglycerol having one or two medium-chain fatty acid residues in a molecule and containing, as constituent fatty acids, a C6-12 medium-chain fatty acid and a C16-24 long-chain fatty acid; and the emulsifier being at least one selected from the group consisting of a phospholipid, a sucrose fatty acid ester, a polyglycerol fatty acid ester, and a glycerol mono-fatty acid ester.

Description

technical field [0001] The invention relates to a fat composition for promoting insulin secretion, and relates in detail to a kind of fat composition for promoting insulin secretion which uses a specific triacylglycerol and a specific emulsifier as active ingredients. Background technique [0002] Diabetes is broadly classified into type I diabetes (insulin-dependent diabetes) and type II diabetes (non-insulin-dependent diabetes). Most diabetics in Japan suffer from type 2 diabetes. It is a disease caused by aggravation of symptoms of insulin insufficiency in which insulin secretion is reduced, or insulin resistance in which the effect of insulin on lowering blood sugar is weakened. These symptoms have a lot to do with genetic factors, partial eclipse, overeating, lack of exercise, stress and other environmental factors. [0003] In recent years, the number of people with type 2 diabetes has continued to increase, reaching 20 million when pre-diabetes, known as borderline ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/23A23L1/30A23L2/52A61K31/231A61K31/232A61K31/685A61K31/7024A61P3/10A61P43/00
CPCA61K31/23A23L1/035A23L1/3006A23L2/52A23V2002/00A61K9/10A61K31/231A61K31/232A61K31/685A61K31/7024A23L29/10A23L33/115A61P3/10A61P43/00A23V2200/328A23V2250/184A23V2250/186
Inventor 青山敏明寺田新
Owner THE NISSHIN OILLIO GRP LTD
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