Gel used for skin diseases and preparation method thereof

Abstract

The invention discloses a gel for skin diseases. The gel is formulated with carboxymethyl chitosan as the main active ingredient, and its raw materials include: carboxymethyl chitosan, stearic acid, monostearin glycerol ester, potassium carbonate, triethanolamine, glycerin, paeonol and purified water. The preparation method includes: 1. weighing; 2. taking the matrix made of stearic acid, potassium carbonate, glycerol monostearate, triethanolamine, glycerin and purified water, and heating; 3. adding paeonol, Stir evenly to obtain an ointment; ④ add carboxymethyl chitosan to purified water, stir to dissolve it, and then add it to the ointment; ⑤ Stir slowly to form a gel to obtain the finished product. The gel of the present invention has the functions of sterilization, anti-inflammatory, antipruritic, scar reduction, moisturizing and skin care; it has the advantages of good stability, good bactericidal effect and convenient use, and is suitable for acne vulgaris, skin eczema, photosensitive dermatitis and other skin disease.

Description

technical field

[0001] The present invention relates to medical dressings, in particular to dressings containing gels of chitosan derivatives, in particular to gels for skin diseases. Background technique

[0002] Chitosan (chitosan) is the only positively charged branched polysaccharide in nature. It has antibacterial, antitumor, immune enhancement and other functions. It has good biocompatibility and is non-irritating and non-toxic. Due to 2- NH 2 Chitosan has a certain antibacterial function, but the antibacterial performance is limited, and is affected by conditions such as chitosan molecular weight and deacetylation degree. After grafting quaternary ammonium salt on the molecular chain of chitosan, its antibacterial performance can be significantly improved. As a natural polycation, chitosan is easy to accumulate in the cell wall, preventing nutrients from entering the cell through the cell wall, causing cell failure and death; while low molecular weight chitosan can ...