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Application of Eryngiolide A in anti-platelet aggregation medicines

An anti-platelet aggregation and drug technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, blood diseases, etc., can solve urgent and minor adverse reactions and other problems

Inactive Publication Date: 2013-06-05
吴俊华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently commonly used antiplatelet drugs have severe adverse reactions, so it is urgent to develop new effective drugs for the treatment and prevention of platelet aggregation with less adverse reactions

Method used

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  • Application of Eryngiolide A in anti-platelet aggregation medicines
  • Application of Eryngiolide A in anti-platelet aggregation medicines
  • Application of Eryngiolide A in anti-platelet aggregation medicines

Examples

Experimental program
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Effect test

Embodiment 1

[0011] Embodiment 1: Preparation of the compound Eryngiolide A tablet involved in the present invention:

[0012] Take 20 grams of compound Eryngiolide A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.

Embodiment 2

[0013] Embodiment 2: the preparation of the compound Eryngiolide A capsule of the present invention:

[0014] Get 20 grams of compound Eryngiolide A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

[0016] The following examples illustrate the invention in more detail without limiting it in any way.

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PUM

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Abstract

The invention relates to application of Eryngiolide A in preparation of anti-platelet aggregation medicines. Use of the Eryngiolide A in preparation of anti-platelet aggregation medicines is made public for the first time, the skeleton type is completely novel, and the Eryngiolide A has an unexpectedly high anti-platelet aggregation inhibitory activity, probability of other compounds giving any revelation for the Eryngiolide A does not exist, outstanding substantive features are provided, meanwhile, prominent improvement is evidently possessed in anti-platelet aggregation.

Description

technical field [0001] The present invention relates to the new application of Eryngiolide A, more specifically relates to the application of this compound in the preparation of anti-platelet aggregation drugs. Background technique [0002] The basic physiological functions of platelets are adhesion, aggregation, release and secretion of granule contents (such as ATP, 5-hydroxytryptamine). After activation, platelets can provide a phospholipid surface, promote blood coagulation, and form a thrombus composed of fibrin surrounding platelets. Therefore, as a formed component of blood, platelets play a very important role in the process of physiological hemostasis and pathological thrombus formation. Clinical studies have shown that common cardiovascular and cerebrovascular diseases such as hypertension, angina pectoris, myocardial infarction, cerebral infarction and cerebral hemorrhage are basically related to changes in platelet function and abnormal hemorheology. Currently ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P7/02
Inventor 黄蓉施桦李媛媛吴俊华
Owner 吴俊华
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