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Inhibition of microbial growth by aconitase inhibition

An aconitase and inhibitor technology, which is applied in the field of inhibiting aconitase activity of fungal cells, and can solve problems such as unknown mechanism

Inactive Publication Date: 2013-06-19
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

From this and other observations, it is thought that copper enhances the growth inhibitory effect induced by ZPT, but the mechanism is unknown

Method used

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  • Inhibition of microbial growth by aconitase inhibition

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Embodiment Construction

[0006] While the specification concludes with claims that particularly point out and distinctly claim the invention, it is believed that the invention will be better understood from the following description.

[0007] The present invention may comprise, consist of, or consist essentially of the essential elements and limitations of the invention described herein, as well as any additional or optional ingredients, components or limitations described herein.

[0008] All percentages, parts and ratios are based on the total weight of the compositions of the present invention, unless otherwise specified. All such weights as they pertain to listed ingredients are based on the active level and, therefore, do not include carriers or by-products that may be included in commercially available materials.

[0009] Components and / or steps of various embodiments of the present invention, including those that may be added optionally, are described in detail below.

[0010] All cited docume...

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Abstract

The present invention is directed to a method of inhibiting aconitase activity of fungal cells in an individual, the method comprising administering an inhibitor of aconitase activity to the fungal cell in an amount effective to inhibit activity of aconitase by said fungal cells.

Description

technical field [0001] The present invention relates to a method of inhibiting the aconitase activity of a fungal cell in an individual, said method comprising administering to said fungal cell an inhibitor of aconitase activity in an amount effective to inhibit the aconitase activity of said fungal cell . Background technique [0002] Without being bound by theory, the antifungal mechanism of action of pyrithione-containing antifungal agents is believed to involve inhibition of aconitase and other mitochondrial iron-sulfur proteins. The mechanism of inhibition is thought to involve the intracellular formation of copper pyrithione by binding to exogenous or endogenous copper and transchelation according to the Irving-Williams series. Copper pyrithione can then penetrate the mitochondrial membrane and interact with iron-sulfur proteins such as aconitase, causing changes in the iron-sulfur active site and resulting inhibition of activity. [0003] In the present invention, Z...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P17/00A61P31/10A61K8/49A61K31/555A61Q5/00A61K31/00
CPCA61K8/19A61K8/22A61K8/362A61K8/368A61K8/4926A61K8/4933A61K8/4953A61K8/66A61K8/69A61K31/4412A61K31/47A61K31/4745A61K31/555A61K2800/782A61P17/00A61P17/08A61P31/10A61P43/00A61Q5/006
Inventor J·R·施瓦茨C·W·桑德斯R·S·扬奎斯特
Owner THE PROCTER & GAMBLE COMPANY
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