Percutaneous absorption plaster for treating degenerative osteoarthropathy

A bone and joint pain, degenerative technology, applied in the field of medicine, can solve the problem of cantharid with large poison, and achieve the effect of overcoming adverse effects, less harm, and avoiding first-pass effect.

Inactive Publication Date: 2013-07-03
崔建平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned drugs have some restrictions when taken internally, for example: mylabris is very poi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0014] Example 1

[0015] A transdermal absorption patch for the treatment of degenerative bone and joint pain, prepared according to the following method:

[0016] (1) Weigh the following raw materials in parts by weight: 0.1 part of Cantharidin; 3 parts of Chuanwu; 7 parts of Caowu; 2 parts of Yuanhu; 2 parts of Chuanxiong;

[0017] (2) Extract the raw materials with a 60% ethanol aqueous solution by volume percentage to obtain the extract; (3) Add borneol to make a rubber paste.

Example Embodiment

[0018] Example 2

[0019] A transdermal absorption patch for the treatment of degenerative bone and joint pain, prepared according to the following method:

[0020] (1) Weigh the following raw materials in parts by weight: 0.03 parts of Cantharidum; 0.3 parts of Chuanwu; 15 parts of Caowu; 1 part of Yuanhu; 2 parts of Chuanxiong;

[0021] (2) Extract the raw materials with a 75% ethanol aqueous solution by volume percentage to obtain an extract;

[0022] (3) Add clove oil to make a rubber paste.

Example Embodiment

[0023] Example 3

[0024] A transdermal absorption patch for the treatment of degenerative bone and joint pain, prepared according to the following method:

[0025] (1) Weigh the following raw materials in parts by weight: 0.24 parts of Cantharidin; 0.5 parts of Chuanwu; 0.5 parts of Caowu; 2 parts of Yuanhu; 3 parts of Chuanxiong;

[0026] (2) Extract the raw materials with a 40% ethanol aqueous solution to obtain an extract;

[0027] (3) Add peppermint oil to make rubber ointment.

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PUM

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Abstract

The invention discloses a percutaneous absorption plaster for treating degenerative osteoarthropathy, which is prepared by the following raw materials: 0.01-0.3 parts of mylabris, 0.3-6 parts of monkshood, 0.5-15 parts of Aconitum kusnezoffii, 1-3 parts of rhizoma corydalis and 1-3 parts of Ligusticum wallichii; 2) extracting the raw materials by an ethanol aqueous solution to obtain an extract product; and 3) adding a percutaneous penetration enhancer to prepare the percutaneous absorption plaster. By using a percutaneous targeting drug delivery system, the percutaneous absorption plaster enables long-time continuous drug delivery, can keep necessary plasma concentration, overcome the adverse influence on human body when the plasma concentration reaches a peak value after oral drug administration, the first pass effect can be avoided, the percutaneous absorption plaster has little harm to liver and kidney, and the simultaneous treatment of principal and subordinate symptoms can be reached.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a transdermal absorption patch for treating degenerative bone and joint pain. Background technique [0002] Degenerative arthritis, also known as hypertrophic arthritis, refers to some elderly people who often have low back pain, leg pain, and joint pain. Because it is more common in the elderly, it is also called senile arthritis. Aging degeneration is the main cause of degenerative arthritis. After middle-aged and old age, degenerative changes will occur in all tissues and organs; bone and joint tissues are no exception. Degenerative changes are especially common in load-bearing joints and multi-movable joints. Excessive weight bearing or overuse of certain joints can promote degenerative changes. In addition, factors such as intra-articular fractures, diabetes, and long-term inappropriate use of corticosteroids can promote the formation of degenerative changes and accelerate ...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/70A61K47/10A61K47/44A61P19/02A61P29/00A61K35/64
Inventor 崔建平
Owner 崔建平
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