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Purposes of artemisinin compounds in preparing anti-atherosclerotic medicaments

A technology for atherosclerosis and artemisinin is applied in the field of biomedicine to achieve the effects of high safety, safe drug selection and low price

Inactive Publication Date: 2013-08-07
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of artemisinin and its derivatives in reducing blood lipid and anti-atherosclerosis has not been reported.

Method used

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  • Purposes of artemisinin compounds in preparing anti-atherosclerotic medicaments
  • Purposes of artemisinin compounds in preparing anti-atherosclerotic medicaments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1, high-fat diet feeds rats to form lipid metabolism disorder model

[0024] 70 male SD rats, weighing 160-180 g, were fed for 5 days adaptively. The animals were stratified according to body weight and randomly divided into 7 groups with 10 rats in each group. The high-fat feed ratio is as follows: 10% lard, 2% cholesterol, 0.2% propylthiouracil, 0.5% pig bile salt, and 87.3% basal feed. The animals were fed with high-fat feed for modeling (except the normal group) and were given artemisinin or its derivatives for 19 consecutive days. On the 20th day, the rats were anesthetized with 25% urethane (0.4ml / 100g), blood was collected through the abdominal aorta, and the serum was centrifuged to measure triglyceride (TG), cholesterol (CHO), high-density lipoprotein (HDL-C ), low-density lipoprotein (LDL-C), the results are shown in Table 1 and Table 2, as can be seen from Table 1, artemisinin and its derivatives can significantly reduce triglyceride and cholest...

Embodiment 2

[0034] Embodiment 2, New Zealand white rabbit fed with high-fat diet forms atherosclerosis model

[0035] 70 male New Zealand white rabbits, weighing 2kg, were fed for 7 days adaptively. The animals were stratified according to body weight and randomly divided into 7 groups with 10 rabbits in each group. The animals were fed with high-fat feed for modeling (except the normal group) and were given artemisinin or its derivatives for 2 consecutive months. After the experiment, blood was collected through the ear vein, and the serum was centrifuged to measure TG and CHO. The experimental results are shown in Table 3. It can be seen from Table 3 that artemisinin and its derivatives can significantly reduce TG and CHO in the serum of high-fat white rabbits. Among them, the effect of artemisinin and its derivatives on reducing triglycerides was significantly better than that of atorvastatin group, and the effect of artesunate was the best; the aorta and liver were separated, and oi...

Embodiment 3

[0042] Artesunate 10g, hydroxypropyl methylcellulose 80g, polyvinylpyrrolidone 100g, lactose 85g, micronized silica gel 100g.

[0043] Mix the prescribed amount of artesunate with the slow-release agent (hydroxypropyl methylcellulose and lactose), add the binder polyvinylpyrrolidone plasmid, dry at 40°C to 80°C, and dry the granules. Add the prescribed amount of lubricant micro-powder silica gel to the granules, mix well, and punch out shaped tablets. Dihydroartemisinin, artesunate, and artemether can all be prepared into tablets of corresponding specifications with reference to Example 3.

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PUM

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Abstract

The present invention discloses purposes of artemisinin compounds in preparing anti-atherosclerotic medicaments. The artemisinin compounds are artemisinin, artesunate, dihydroartemisinin or artemether. The artemisinin compounds may be prepared to be any kind of pharmaceutically acceptable preparation. The present invention has exploited new medical purposes of the artemisinin compounds, overcoming the shortages of prior anti-atherosclerosis drugs; treatment effects are brought into play from two ways of anti-inflammatory and lipid-lowering; while the artemisinin compounds are reference listed drugs of China and are mainly produced in China, thus having wide sources, low prices; and the artemisinin compounds have strong pharmacological effects, high security, providing an economical, safe drug selection for the mass patients with cardiovascular diseases.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the use of artemisinin compounds in the preparation of anti-atherosclerotic drugs. Background technique [0002] Atherosclerosis (AS) is a common cardiovascular disease in modern society, mainly manifested as lipid deposition in the arterial intima, focal fibrosis in the intima, and formation of atherosclerotic plaques, resulting in hardening of the vessel wall and the deterioration of the lumen. Stenosis, and then cause a series of secondary lesions, especially easy to cause ischemic diseases in cardiovascular and cerebrovascular, etc., is the number one killer of human beings in today's society. The pathogenesis of atherosclerosis is complex, and hyperlipidemia and inflammation are considered to be the two most important pathogenic factors. The current main strategy to prevent and treat atherosclerosis is lipid-lowering. There are five types of lipid-lowering drugs commonly used: st...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61K31/357A61P9/10
Inventor 唐克轩王玉亮
Owner SHANGHAI JIAO TONG UNIV
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