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Method for measuring packing volume of capsule powder

A measurement method and powder technology, applied in the direction of volume measurement instrument/method, container/cavity capacity measurement, measurement device, etc., can solve the problems of limited monitoring of capsule particle weight, difficult maintenance, unfavorable promotion, etc., to facilitate promotion The effect of low cost of use and implementation and low anti-interference

Active Publication Date: 2013-08-07
韩杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The weighing process of various mechanical balances and electronic balances requires manual operation. The disadvantages are: slow detection speed, low efficiency, and cumbersome operation; online automatic weighing cannot be realized, and it can only be used for random inspection, and it is impossible to realize capsule-by-capsule Weighing, this method is extremely limited in monitoring the capsule grain weight, and there are still many capsules whose grain weight does not meet the requirements cannot be detected
Although various devices using the principle of weight sensors have greatly improved their work efficiency and can weigh capsules one by one, they also have significant disadvantages: the equipment is precise and expensive, which is not conducive to promotion in pharmaceutical companies; the system is complex and difficult to maintain. , high maintenance cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Choose a container whose volume can be changed, such as a container with at least part of the wall being elastic, or a cylinder, etc. Put the capsule to be tested into the container and seal the container. At this time, the volume of the container is the initial value V1.

[0015] Apply pressure to the elastic wall or piston of the container by external force, so that the volume of the container is compressed and reduced to V2. During this process, the gas in the container is compressed and the air pressure gradually rises. The compressed air will pass through the cap of the capsule body. The gap between them enters the inside of the capsule, so the gas inside the capsule is also compressed, and the air pressure will gradually rise until it rises to P2 the same as the air pressure in the container.

[0016] According to Boyle's law: P1(V1-V0-V)=P2(V2-V0-V), wherein, V0 is the volume of the capsule shell itself known in advance, and V represents the volume of the powder ...

Embodiment 2

[0018] Similar to Embodiment 1, a container with a variable volume should be selected first, the capsule to be tested is put into the container, and the container is sealed. At this time, the volume of the container is the initial value V1.

[0019] The external force applies a pulling force to the elastic wall or piston of the container to expand the volume of the container to V2. During this process, the gas in the container becomes thinner and the air pressure gradually decreases. At the same time, the air inside the capsule will also pass through the capsule. The gap between the caps of the body capsule leaks out, eventually making the air pressure inside the capsule drop to P2 as in the container.

[0020] Same as Embodiment 1, according to Boyle's law: P1(V1-V0-V)=P2(V2-V0-V), wherein, V0 is the volume of the capsule shell itself known in advance, and V represents the capsule The volume of the medicine powder in the capsule can thus calculate the volume of the medicine p...

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Abstract

The invention relates to a method for measuring the packing volume of the capsule powder, which comprises the following steps: putting the capsule into a volume changeable sealed container, and changing the air pressure of the air in the container through the method of exerting external force compressing or expanding the container volume under the premise that the total amount of the air in the container is kept to be unchanged, thereby measuring the volume of the powder in the capsule according to the change of the air pressure. The method has the advantages that the method is simple, convenient, and feasible; and the implement cost is low.

Description

technical field [0001] The invention relates to a measuring method for determining the volume of a non-gas substance, in particular to a method for measuring the content of medicine powder filled in a capsule. Background technique [0002] In the field of pharmaceutical industry, due to the influence of various factors such as the stability of the capsule filling equipment itself and the characteristics of the medicinal powder itself, the weight of the medicinal powder contained in the capsule, that is, the capsule grain weight, fluctuates during the production process of the capsule. As far as drugs for diseases are concerned, the amount of drug contained in a unit dose, that is, the grain weight of each capsule must be stabilized within a narrow range, so pharmaceutical companies will strictly control and measure the grain weight of capsules, and test And remove the defective products whose grain weight does not meet the requirements. [0003] The current method of measur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01F17/00
Inventor 韩杰
Owner 韩杰
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