Compound supercritical extractant of ligusticum wallichii and baked ginger, and preparation method of transdermal drug delivery preparation of compound supercritical extractant for promoting postpartum uterine involution

A technology of supercritical extract, Ligusticum chuanxiong Paojiang, which is applied in the preparation of transdermal drug preparations for postpartum uterine involution, and in the field of supercritical extracts, can solve the problems of poor uterus and natural childbirth, and achieve high separation efficiency, stable and reliable methods Good repeatability and spreadability

Inactive Publication Date: 2013-08-14
ZHEJIANG PHARMA COLLEGE
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Problems solved by technology

In recent years, the cesarean section rate has shown an obvious upward trend, but many studies have shown that uterine involution after cesarean section is significantly worse than natural childbirth

Method used

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Embodiment 1

[0029] Example 1 Preparation of Supercritical Extract of Chuanxiong Paojiang Compound and Its Transdermal Preparation

[0030] The preparation method of Chuanxiong Paojiang compound supercritical extract, the method comprises the following steps:

[0031] 1) Take Chuanxiong Paojiang medicinal material, mix it according to the ratio of 9:2, crush it into large mung bean particles, and set aside;

[0032] 2) Take the mixed particles from step 1) and put them into a supercritical extractor reactor. The extraction conditions are extraction pressure 300bar, extraction time 1.5h, extraction temperature 60°C, analysis temperature 70°C, and perform CO2 supercritical extraction;

[0033] 3) Take the extract from step 2), let it cool to room temperature, and obtain the supercritical extract of Chuanxiong Paojiang compound;

[0034] 4) Take the prescribed amount of extract from step 3), add ethanol to dissolve it, and set aside.

[0035] 5) Prepare carbomer-940 into a 4% concentrated...

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Abstract

The invention discloses a compound supercritical extractant of ligusticum wallichii and baked ginger. The total lactone content of the extractant is not less than 35%; and the total terpene content is not less than 25%. The preparation method comprises the following steps of 1) crushing the ligusticum wallichii and the baked ginger into coarse particles by a shatter after mixing according to the ratio; 2) putting the coarse particles in the step 1) into a supercritical extractor, and extracting according to the optimized condition; and 3) cooling the extract to room temperature, so as to obtain the supercritical extractant. The invention also provides application of the extractant, and preparation of a transdermal drug delivery preparation for promoting postpartum uterine involution. The compound supercritical extractant has the following advantages that 1, the adopted technological means for extraction and separation are novel; 2, the separation efficiency is high; 3, the method is stable and can be repeatable; and 4, transdermal gel is fine and smooth, and good in coating property; and transdermal permeation of the drug can be effectively promoted.

Description

technical field [0001] The invention relates to a medicine field, in particular to the preparation of a supercritical extract of traditional Chinese medicine Chuanxiong and Paojiang compound, and a transdermal preparation for promoting postpartum uterine involution. Background technique [0002] Ligusticum chuanxiong Ligusticum Chuanxiong The dried rhizome of Hort, pungent in taste, slightly bitter, warm in nature, returns to the Liver, Gallbladder, and Pericardium Meridians. It has the effects of promoting blood circulation and dispelling diseases, promoting qi to relieve depression, expelling wind and relieving pain, and is used to treat cardiovascular diseases and gynecological diseases. The active ingredients of Ligusticum chuanxiong are alkaloids represented by ligustrazine, organic acids represented by ferulic acid, and phthalides represented by ligustilide and ligustilide. Clinically, it is mainly used to treat headache, rheumatic arthralgia, irregular menstruation,...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/00A61P15/00
Inventor 钦富华夏晓静胡英王明军
Owner ZHEJIANG PHARMA COLLEGE
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