Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

High-efficiency bifidobacterium bifidum induced by space mutagenesis, its application and preparation method of capsule preparation

A bifidobacterium bifidum and space mutagenesis technology, applied in the field of microorganisms, can solve the problems of difficult production of live bacterial preparations, instability of bifidobacteria mutant strains, easy inactivation of preservation and oral administration, etc., to achieve the treatment of indigestion, Effects of regulating the balance of intestinal flora and improving acid and salt tolerance

Active Publication Date: 2014-10-29
神舟太空集团(深圳)高科技有限公司
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although "replenishment of live bacteria in vitro" avoids the unsafe problems brought about by the method of "proliferation of live bacteria in vivo", bifidobacteria are a strict anaerobic bacteria, and the production of live bacteria preparations is difficult, and due to the impact of live bacteria on Sensitive to acids, bases, and heat, making preservation and oral inactivation prone
At the same time, the mutant strains of bifidobacterium induced by conventional mutagenesis are unstable, which causes greater difficulties in the production of live bacterial preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • High-efficiency bifidobacterium bifidum induced by space mutagenesis, its application and preparation method of capsule preparation
  • High-efficiency bifidobacterium bifidum induced by space mutagenesis, its application and preparation method of capsule preparation
  • High-efficiency bifidobacterium bifidum induced by space mutagenesis, its application and preparation method of capsule preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0067] The present invention will be described in detail below in combination with specific embodiments.

[0068] A high-efficiency space mutagenesis Bifidobacterium bifidum (Bifidobacterium bifidum) S7-T5 described in the present invention was preserved on May 19, 2011 in the General Microbiology Center of China Microbiological Culture Collection Management Committee, the address is Beichen, Chaoyang District, Beijing No. 3, No. 1 Yard, West Road, Institute of Microbiology, Chinese Academy of Sciences, the deposit number is CGMCC No. 4886.

[0069] 1. Mutagenesis of Bifidobacterium bifidum:

[0070] Bifidobacterium bifidum with the preservation number CGMCC 1.2212 was used as the starting strain, and the number was S7-D5, which was divided into 2 parts, 1 part was stored at 4°C as a ground control strain, and 1 part was used as a carrying strain to carry the Shenzhou VII manned spacecraft Perform steric mutagenesis.

[0071] Second, the preparation and cultivation of bacter...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a space-induced efficient bifidobacterium bifidum and application thereof as well as a preparation method of a capsule preparation of the space-induced efficient bifidobacterium bifidum. Bifidobacterium bifidum is strict anaerobic bacteria; the active microbial agents of the bifidobacterium bifidum are difficultly produced; and the viable organism is sensitive to acid, alkali and heat, so that inactivation is easily caused by storage and oral administration. The invention provides a bifidobacterium bifidum (Bifidobacterium bifidum) S7-T5 which can be applied to preparation of a medicine and a health-care product for adjusting balance of intestinal flora. The oxygen-resistant characteristics, the acid-resistant characteristics and the salt-tolerant characteristics of the bifidobacterium bifidum disclosed by the invention are obviously improved; and the bifidobacterium bifidum has stable hereditary and industrial characteristics. A living bacterium capsule preparation produced by the strain S7-T5 disclosed by the invention can improve digestion, adjust intestinal flora balance, treat diarrhea and dyspepsia by clinical verification, can be applied to bifidobacterium bifidum health-care products and bifidobacterium bifidum medicine, and has a wide application prospect.

Description

technical field [0001] The invention relates to the technical field of microbes, in particular to a strain of Bifidobacterium bifidum with high efficiency of space mutagenesis, its application and a preparation method of a capsule preparation. Background technique [0002] Bifidobacterium bifidum, Latin scientific name Bifidobacterium bifidum , a type species of the genus Bifidobacterium. Bifidobacterium Orla-Jensen is an anaerobic Gram-positive bacillus isolated from the feces of breast-fed infants by French scholar Tissier in 1899. The ends are often forked, hence the name Bifidobacterium. Bifidobacterium is a physiological bacterium in the human gastrointestinal tract. It is a beneficial bacterium. It is inseparable from the health of the human body. The most common distribution is in breast-fed infants. Bifidobacterium not only has many benefits for infants and young children, such as nutrition, immunity and anti-infection, but also has anti-allergy, anti-tumor, liver...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A23L1/29A61K35/74A61K9/48A61P1/00C12R1/01A23L33/00A61K35/745
Inventor 赵恒
Owner 神舟太空集团(深圳)高科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com