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Felbinac-containing external patch

A technology of felbinac and patch, which is applied in the field of percutaneously absorbable external anti-inflammatory and analgesic preparations, can solve unexpected problems, achieve high drug stability, excellent drug release, and low skin irritation

Active Publication Date: 2013-08-28
TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] However, it is known that the rosin-based resin compounded in this patch acts as a skin allergy component, and this compounding is not expected.

Method used

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  • Felbinac-containing external patch
  • Felbinac-containing external patch
  • Felbinac-containing external patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] After kneading and melting SIS, polybutene, liquid paraffin, and dibutyl hydroxytoluene at 170°C, add alicyclic saturated hydrocarbon resin, knead and mix at 130°C to produce Adhesive base.

[0063] Further, a felbinac dispersion liquid was prepared by uniformly dispersing felbinac having an average particle diameter of 5 μm to less than 100 μm in a liquid mixed with diethyl sebacate and an appropriate amount of mobile paraffin while stirring. The felbinac dispersion was added to the above-mentioned adhesive base, and kneaded until uniformly dispersed to prepare an adhesive. The adhesive was coated on a silicone-treated polyethylene terephthalate film in a thickness of 100 μm, and then laminated with a polyester woven cloth to obtain a test preparation.

Embodiment 2～16

[0065] In the same procedure as in Example 1, according to the component compositions shown in Tables 1 to 3, the target patch of the present invention was produced.

[0066] [Table 1]

[0067]

[0068] [Table 2]

[0069]

[0070] [table 3]

[0071]

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PUM

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Abstract

Provided is a felbinac-containing external patch that shows a high drug release property and also low skin irritation, and is capable of exerting high drug stability. This felbinac-containing external patch is characterized in that L-menthol is not contained, and felbinac having an average particle size of 5 [mu]m or more but less than 100 [mu]m is dispersed to mix with an adhesive base that is composed of styrene-isoprene-styrene block copolymer, alicyclic saturated hydrocarbon resin, softener, and diethyl sebacate, specifically, 0.1 to 10% by weight of felbinac having an average particle size of 5 [mu]m or more but less than 100 [mu]m is dispersed to mix with an adhesive base that is composed of 10 to 30% by weight of styrene-isoprene-styrene block copolymer, 10 to 50% by weight of alicyclic saturated hydrocarbon resin, 10 to 75% by weight of softener, and 0.1 to 10% by weight of diethyl sebacate.

Description

technical field [0001] The present invention relates to a percutaneous absorbable external anti-inflammatory and analgesic preparation, and more specifically relates to an anti-inflammatory and analgesic external patch containing felbinac, which exhibits good drug release, low skin irritation and high drug stability. Background technique [0002] Felbinac (Felbinac: 4-felbinac) is an active metabolite of the non-steroidal anti-inflammatory and analgesic drug fenbufen, and it is a drug that exhibits strong anti-inflammatory and analgesic effects. If felbinac is administered orally, there are problems of side effects on the digestive system and gastrointestinal disorders, so studies have been conducted as transdermal preparations, and so far, external preparations such as gels and liquids are commercially available . [0003] However, dosage forms such as gels and liquids have problems such as difficulty in quantitative administration, low bioavailability, and adhesion of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K9/70A61K47/14A61K47/32A61P29/00
CPCA61K9/7053A61K31/192A61P19/02A61P21/00A61P25/04A61P29/00A61K47/14A61K47/32A61K2121/00A61K9/7007
Inventor 猪尾胜幸
Owner TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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