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Veterinary amoxicillin-sulbactam suspension injection and preparation method thereof

A technology for suspension injection and amoxicillin, which is applied in the field of suspension injection and its preparation, can solve the problems such as quality requirements that cannot meet the validity period, poor stability, etc., and achieves low production cost, prolonged stability, and easy availability of raw materials. Effect

Inactive Publication Date: 2013-09-18
CHONGQING FANGTONG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are generally disadvantages of poor stability, which cannot meet the quality requirements of the validity period.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Amoxicillin 5%, sulbactam 0.15%, aluminum stearate 5%, benzyl alcohol 0.5%, injection oil to 100%.

[0016] Preparation process: Take half the amount of oil for injection, add aluminum stearate, and dissolve it in a water bath at 40°C. After adding benzyl alcohol and stirring evenly, add amoxicillin, sulbactam, and oil for injection to the full amount, pass through a homogenizer twice at a pressure of 20-30Mpa, mix evenly, and fill to obtain the product.

Embodiment 2

[0018] Amoxicillin 10%, sulbactam 0.25%, aluminum stearate 8%, chlorobutanol 1.8%, injection oil to 100%.

[0019] Preparation process: Take half the amount of oil for injection, add aluminum stearate and stir to dissolve it. After adding benzyl alcohol and stirring evenly, add amoxicillin, sulbactam, and oil for injection to the full amount, pass through a homogenizer twice at a pressure of 20-30Mpa, mix evenly, and fill to obtain the product.

Embodiment 3

[0021] Amoxicillin 20%, sulbactam 1%, aluminum stearate 10%, chlorobutanol 3%, injection oil to 100%.

[0022] Preparation process: with embodiment 1.

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Abstract

The invention relates to a veterinary drug, in particular to a stable, efficient and broad-spectrum veterinary amoxicillin-sulbactam suspension injection and a preparation method thereof. The pharmaceutical composition of the veterinary amoxicillin-sulbactam suspension injection comprises the following ingredients by volume weight: 5%-30% (w / v) of amoxicillin, 0.15%-5% (w / v) of sulbactam, 5%-20% (w / v) of suspending agent, 0.3%-8% (w / v) of antimicrobial preservative, and the balance of injection oil, wherein the suspending agent is aluminum stearate, and the antimicrobial preservative is benzyl alcohol or acetone chloroform. Specific raw materials and proportions are selected to greatly prolong the stability of the amoxicillin-sulbactam suspension injection, and meanwhile, the raw materials are simple and available, the processing technique is simple, the operation is convenient and the production cost is low.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to a compound suspension injection composed of amoxicillin and sulbactam and a preparation method thereof. Background technique [0002] Amoxicillin is a β-lactam antibiotic commonly used in veterinary clinics. It has a broad spectrum but is intolerant to enzymes. Bacteria can produce β-lactamase to make the drug lose its antibacterial activity. Sulbactam is a β-lactamase inhibitor, which inhibits the production of β-lactamase by bacteria by competing for the active site of β-lactamase, so that antibiotics can produce applied antibacterial effects. [0003] The compound preparation of the amoxicillin-sulbactam pharmaceutical composition has large clinical usage, definite curative effect and good market prospect. However, there are generally disadvantages of poor stability, which cannot meet the quality requirements of the validity period. Contents of the invention [0004] The main purpose o...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/43A61P31/04
Inventor 唐建华龚聪宋小红
Owner CHONGQING FANGTONG ANIMAL PHARMA
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