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Radix isatidis coating dispersible tablet and preparation method thereof

A technology of isatidis and dispersible tablets, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problem that the dissolution rate and dissolution rate need to be further improved, affect the taste and curative effect, and cause bad smell and other issues to achieve the effect of ensuring product efficacy, no degradation and loss, and good stability

Active Publication Date: 2015-07-08
JIANGSU PENGYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Application number CN200910017928.X and application number CN200410025111.4 patents all disclose a kind of Radix Radix Radix dispersible tablet and its preparation process, but all are bare chips with heavy bad smell and bad taste. Long-term storage is prone to moisture, which affects the taste and curative effect. In addition, the disintegration time of the above-mentioned dispersible tablets exceeds 100s, and the dissolution rate and dissolution rate need to be further improved.

Method used

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  • Radix isatidis coating dispersible tablet and preparation method thereof
  • Radix isatidis coating dispersible tablet and preparation method thereof
  • Radix isatidis coating dispersible tablet and preparation method thereof

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Embodiment Construction

[0024] The present invention is further described below in conjunction with embodiment, so that understand the present invention and its advantage and effect more deeply.

[0025] Unless otherwise specified, the raw materials and reagents involved in the following examples are all domestic or imported analytically pure products, and all the instruments and equipment used are conventional equipment in this field.

[0026] Preparation Examples of Isatidis Coated Dispersible Tablets (Example 1~Example 4)

[0027] Refer to Table 1 for the raw materials and weight ratios for the preparation of Radix isatidis coated dispersible tablet cores in Examples 1 to 4.

[0028] The extraction process of Radix isatidis is as follows:

[0029] Take 10 kg of commercially available Banlangen decoction pieces and crush them into coarse powder, add 10 times the weight of water to decoct for 60 minutes for the first time, filter to obtain the filtrate, add 8 times the weight of water to decoct fo...

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Abstract

The invention provides a radix isatidis coating dispersible tablet and a preparation method thereof. A dispersible tablet core is prepared from the following raw materials in parts by weight: 20-30 parts of extraction of radix isatidis, 40-60 parts of microcrystalline cellulose, 10-15 parts of low substituted hydroxy propyl cellulose, 4-8 parts of croscarmellose sodium, 0.5-1 part of lauryl sodium sulfate, 0.5-1 part of gum acacia, 1-5 parts of lactose, 0-0.5 part of aromatic and 0-0.5 part of corrigent. The method comprises the following steps of carrying out wet granulation, totally mixing, and tabletting to prepare a phi12mm core with the tablet weight of 0.55-0.59g; and carrying out secondary coating to spray a film coating by using an opadry coating solution 1 and an opadry coating solution 2, and packing to obtain a finished product of the dispersible tablet. The radix isatidis coating dispersible tablet has excellent dispersion uniformity, is rapid to disintegrate and good in digesting performance, tablet surfaces of tablets in all the batches are even and have no chromatic aberration; and the tablet has no crack and uncoating phenomena and has good quality stability.

Description

technical field [0001] The invention relates to a dispersible tablet and a preparation process thereof, in particular to a Radix isatidis coated dispersible tablet and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Radix Isatidis is rooted in the roots of cruciferous plants Isatis indigo and Grass Daqing. It is bitter and cold in nature. It is a widely used Chinese herbal medicine. It is mainly used to treat tonsillitis, mumps, sore throat, and has preventive and therapeutic effects on infectious hepatitis and infantile measles. [0003] Currently commercially available Isatidis preparations mainly include oral liquids, granules, and ordinary tablets. A large amount of flavoring agents to adjust the mouthfeel need to be added to the oral and granules, but they still cannot completely cover up the unpleasant bitterness of Isatidis. Not high in sex, and the dose is large at one time, the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/195A61K36/315A61K47/38A61K9/36A61P31/00A61P11/04A61P29/00A61P31/14A61P31/20
Inventor 姚忠周健蒋锋吴洪君王荣昌
Owner JIANGSU PENGYAO PHARMA
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