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Zanthoxylum armatum total alkaloids extract, and preparation method and application thereof

A technology of total alkaloids and extracts, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of no scientific quality control method, unclear target components, affecting clinical use, etc., to achieve good anti-inflammatory effect, good Therapeutic effect, high analgesic and anti-inflammatory effect

Inactive Publication Date: 2013-10-23
LANZHOU UNIVERSITY OF TECHNOLOGY
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Problems solved by technology

Due to its unclear target components and no scientific quality control methods, it has seriously affected clinical use and is currently rare in the market

Method used

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  • Zanthoxylum armatum total alkaloids extract, and preparation method and application thereof
  • Zanthoxylum armatum total alkaloids extract, and preparation method and application thereof
  • Zanthoxylum armatum total alkaloids extract, and preparation method and application thereof

Examples

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Embodiment Construction

[0015] The preparation method of total alkaloid extract of bamboo leaf pepper, its steps are:

[0016] (1) Grinding the roots, stems, leaves and fruits of the pepper, and passing through a 20-100 mesh sieve to obtain the rough fraction of the pepper;

[0017] (2) Extract the rough fraction of bamboo leaf pepper with 50%-95% ethanol, recover the ethanol through filtration, concentrate and obtain the ethanol extract, then use hydrochloric acid, sulfuric acid or other acid reagents to adjust the pH to 1-5, and let it stand Overnight, after filtering, adjust the pH of the filtrate to 9-12 with sodium hydroxide, ammonia water or other alkaline reagents, and let it stand overnight; then extract with chloroform to obtain the total alkaloid extract;

[0018] Or extract the crude fraction of bamboo leaf pepper with 50%-95% ethanol, recover the ethanol through filtration, concentrate to obtain the ethanol extract, disperse the obtained extract with water, extract with petroleum ether an...

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Abstract

A zanthoxylum armatum total alkaloids extract, and a preparation method and an application thereof are provided. The preparation method comprises the steps: (1) smashing roots, stems, leaves and fruits of zanthoxylum armatum, and sieving with a 20-100 mesh sieve to obtain a crude zanthoxylum armatum; (2) extracting the crude zanthoxylum armatum with ethanol in a concentration of 50%-95%, filtering to recover the ethanol, concentrating to obtain an ethanol extract, then adjusting pH to 1-5 with hydrochloric acid, sulfuric acid or other acid reagents, standing overnight, filtering, then adjusting pH of the filtered liquid to 9-12 with sodium hydroxide, aqua ammonia or other alkali reagents, and standing overnight; and then extracting by chloroform to obtain the total alkaloids extract. The extract is used for preparation of drugs for treating pain and inflammation.

Description

technical field [0001] The present invention mainly relates to the field of natural product chemistry, in particular to the application of the effective extract from the bamboo leaf pepper, especially the application in analgesia. Background technique [0002] bamboo leaf pepper ( Zanthoxylum armatum ) is a medicinal plant of the Rutaceae Zanthoxylum bungeanum, and its roots, stems, leaves, fruits and seeds are all used as herbal medicines. It has the effects of expelling wind and cold, promoting qi and relieving pain, and can treat rheumatoid arthritis, toothache, swelling and pain from falls, etc. Bamboo leaf pepper is produced in the south of Shandong, south to Hainan, southeast to Taiwan, southwest to southeast Tibet; it is found in various habitats from low hills to mountains at an altitude of 2200 meters, and limestone mountains are also common. At present, the traditional Chinese medicine Zhuyejiao Tablets (preparation of bamboo leaf pepper ethanol extract) produce...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61P29/00A61P19/02A61P25/04
Inventor 郭涛李永辉袁惠君巩慧玲苏丹
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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