Applications of Chukrasone A in anti-helicobacter pylori medicines
A technology for anti-helicobacter pylori and drugs, which is applied in the field of preparation of anti-helicobacter pylori drugs, can solve problems such as indigestion and the destruction of bacterial flora in the digestive tract, and achieve the effect of strong inhibitory activity and outstanding substantive characteristics
Inactive Publication Date: 2013-11-06
王志红
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Problems solved by technology
The most important factor affecting triple therapy is considered to be the resistance of Hp to antibacterial agents; another serious problem is that proton pump inhibitors can induce indigestion, and a large amount of antibacterial agents can lead to serious destruction of the intestinal flora
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0013] Embodiment 1: the preparation of the compound Chukrasone A tablet involved in the present invention:
[0014] Take 20 grams of compound Chukrasone A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.
Embodiment 2
[0015] Embodiment 2: the preparation of the compound Chukrasone A capsule involved in the present invention:
[0016] Get 20 grams of compound Chukrasone A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.
[0017] The following pharmacodynamic experiments will further illustrate its drug activity.
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In vitro activity experiment indicates that Chukrasone A has excellent inhibitory activity on helicobacter pylori (Hp). Chukrasone A can be used for treating diseases such as acute and chronic gastritis, gastric ulcer and duodenal ulcer, and in preparation of medicines used for treating acute and chronic gastritis, gastric ulcer and duodenal ulcer. Applications of Chukrasone A in preparation of medicines used for treating helicobacter pylori are disclosed for the first time. Due to the fact that skeleton type belongs to completely novel skeleton type, and inhibitory activity of Chukrasone A on helicobacter pylori is unexpectedly high, probability of other compounds giving any revelation for Chukrasone A does not exist, outstanding substantive features are provided, meanwhile, prominent improvement is evidently possessed in treating and preventing helicobacter pylori.
Description
technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to the application of Chukrasone A in the preparation of anti-helicobacter pylori drugs. Background technique [0002] Helicobacter pylori (Hp) is a Gram-negative spiral bacterium. Studies have shown that Helicobacter pylori is the main cause of acute and chronic gastritis and gastric and duodenal ulcers, and may be related to gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) malignant lymphoma. Recently, the World Health Organization classified Hp as a class I carcinogen, which plays a leading role in the development of gastric cancer. The current popular treatment for Hp infection is the triple therapy of proton pump inhibitor (PPI) plus two antibiotics (choose two from clarithromycin, amoxicillin, tetracycline, metronidazole, etc.). The most important factor affecting triple therapy is considered to be the resistance of Hp to antibacteri...
Claims
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IPC IPC(8): A61K31/585A61P31/04
Inventor 丁圣雨
Owner 王志红