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Radix Astragali extract and its preparation method and preparation

A technology of astragalus extract and extraction solvent, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., and can solve the problems of not easy to carry, cumbersome operation, etc.

Active Publication Date: 2015-04-15
SICHUAN ZHIQIANG MEDICINE SCI & TECH DEV LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] According to its functions and indications, Astragalus membranaceus is used for medium and long-term medication. The traditional method of taking it is decoction, which is cumbersome to operate and not easy to carry. Therefore, modern industries make it into preparations, which are convenient to use and carry.

Method used

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  • Radix Astragali extract and its preparation method and preparation
  • Radix Astragali extract and its preparation method and preparation
  • Radix Astragali extract and its preparation method and preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Embodiment 1 of the present invention common sheet

[0041] Take 3750g of astragalus, add water (a mixed solution of disodium hydrogen phosphate and trisodium phosphate 1:1 to adjust the pH value to 9) and decoct twice, add 10 times the amount of water each time, the first time is 3 hours, and the second time is 2 hours , combine the decoction, filter, and concentrate the filtrate under reduced pressure to a clear paste with a relative density of about 1.15 (80°C), add ethanol to make the alcohol content 70%, stir well, let stand, take the supernatant to recover ethanol, concentrate To a clear paste with a relative density of 1.25 (80°C), dry it under reduced pressure at 70°C and -0.07MPa, crush it into a fine powder, and micronize it to D95=10μm to obtain about 375g of Astragalus extract, add 24g of starch , mixed evenly, granulated, added 2 grams of magnesium stearate, mixed evenly, pressed into 1000 tablets, film-coated, and obtained.

Embodiment 2

[0042] Embodiment 2 of the present invention ordinary sheet

[0043] Take 3750g of astragalus, add water (a mixed solution of disodium hydrogen phosphate and trisodium phosphate 1:1 to adjust the pH value to 10) and decoct twice, add 10 times the amount of water each time, the first time is 3 hours, and the second time is 2 hours , combine the decoction, filter, and concentrate the filtrate under reduced pressure to a clear paste with a relative density of about 1.17 (80°C), add ethanol to make the alcohol content 70%, stir well, let stand, take the supernatant to recover ethanol, concentrate To a clear paste with a relative density of 1.26 (80°C), dry it under reduced pressure at 70°C and -0.07MPa, crush it into a fine powder, and micronize it to D95=12μm to obtain about 380g of Astragalus extract, add 28g of starch , mixed evenly, dry granulated, added 2 grams of magnesium stearate, mixed evenly, compressed into 1000 tablets, film-coated, and obtained.

Embodiment 3

[0044] Embodiment 3 of the present invention dispersible tablet

[0045]Take 3750g of astragalus, add water (a mixed solution of disodium hydrogen phosphate and trisodium phosphate 1:1 to adjust the pH value to 9) and decoct twice, add 10 times the amount of water each time, the first time is 3 hours, and the second time is 2 hours , combine the decoction, filter, and concentrate the filtrate under reduced pressure to a clear paste with a relative density of about 1.20 (80°C), add ethanol to make the alcohol content 70%, stir well, let stand, take the supernatant to recover ethanol, concentrate To the clear paste with a relative density of 1.30 (80°C), dry it under reduced pressure at 70°C and -0.07MPa, crush it into a fine powder, and micronize it to D95=9μm to obtain about 360g of Astragalus extract, add microcrystalline fiber 90g plain, mix well, add 10g cross-linked polyvinylpyrrolidone ethanol solution (5%), granulate with 24 mesh, dry at 60°C, pass through 24 mesh sieve ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and relates to Radix Astragali extract and its preparation method and preparation. The Radix Astragali extract is used for treating shortness of breath, palpitaition, collapse, spontaneous perspiration, asthenia and edema, symptoms after tumor chemoradiotherapy and operation, chronic nephrosis, chronic diarrhea, proctoptosia, uterine prolapsed, gynecological diseases, ulcer fester and nonunion wounds. The Radix Astragali extract has obviously improved content of total saponins and astragaloside. The preparation method comprises the following steps of adding water into Radix Astragali, carrying out decoction, filtering the decoction, concentrating the filtrate, adding ethanol into the concentrated filtrate, carrying out standing, collecting a supernatant, recovering the ethanol, carrying out condensation and drying, and carrying out crushing to obtain fine powder. Aiming at solving defects of the existing preparation and satisfying clinical medicine requirements, the inventor carries out detailed research. The Radix Astragali extract as an active component and appropriate medicinal auxiliary materials are processed into the preparation by the conventional processes.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to an extract of Astragalus membranaceus and its preparation method and preparation, which are specifically applied to shortness of breath, heart palpitations, collapse, spontaneous sweating, body deficiency and edema, tumor chemoradiotherapy and surgery, chronic kidney disease, chronic diarrhea, prolapse of the anus, uterus Prolapse, gynecological diseases, carbuncles that are difficult to ulcerate, and sores that do not heal for a long time. Background technique [0002] Astragalus, also known as Astragalus, is mainly distributed in the Altai Mountains in Xinjiang, Daxingan Mountains, Xiaoxingan Mountains, Wanda Mountains, Zhangguangcai Mountains, Laoye Mountains, Changbai Mountains and eastern Liaoning Mountains and Yanshan Mountains, Taishan Mountains, Xiaowutai Mountains, Hengshan Mountains, and North China Mountains in North China. Wutai Mountain, Loess Plateau, Taiyu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481A61P7/10A61P13/12A61P1/12A61P15/00A61P17/02A61P9/00A61P35/00A61P3/10A61P9/12A61P5/00
Inventor 毛兴荣李开县
Owner SICHUAN ZHIQIANG MEDICINE SCI & TECH DEV LTD
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