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Application of stahlianthus involucratus and extractive of stahlianthus involucratus in preparing drugs for treating and/or preventing liver cancer

The technology of extract and Panax notoginseng is applied in the application field of ginger leaf Panax notoginseng and its extract in the preparation of medicines for treating and/or preventing liver cancer, which can solve the problem of liver cancer that has not been disclosed, has not been disclosed, and has not been reported. Issues such as the effect of ginger leaf Panax notoginseng on the cell cycle, proliferation or apoptosis of liver cancer are disclosed, and the effect of high safety is achieved

Inactive Publication Date: 2013-12-04
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In the existing public documents, the volatile oil components of Ginger-leaf Sanqi or the effect of Ginger-leaf Sanqi in treating bruises and other diseases have been mentioned, but there is no public use of Ginger-leaf Sanqi and ginger-leaf Panax notoginseng extracts , Ginger leaf notoginseng fat-soluble extract and ginger leaf notoginseng volatile oil are used to treat tumors and the effect of various cancers. No one has disclosed that ginger leaf notoginseng can be used to treat liver cancer, and there is no report on the effect of ginger leaf notoginseng on the cycle of liver cancer cells. , proliferation or apoptosis

Method used

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  • Application of stahlianthus involucratus and extractive of stahlianthus involucratus in preparing drugs for treating and/or preventing liver cancer
  • Application of stahlianthus involucratus and extractive of stahlianthus involucratus in preparing drugs for treating and/or preventing liver cancer
  • Application of stahlianthus involucratus and extractive of stahlianthus involucratus in preparing drugs for treating and/or preventing liver cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: Ginger leaf Panax notoginseng volatile oil

[0050] Take 150g of fresh ginger leaf notoginseng and crush it into a coarse powder, add 450ml of medicinal materials to soak in distilled water for 0.5h, extract by steam distillation for 3h, collect the essential oil in the upper layer, and obtain 1.7ml of ginger leaf notoginseng volatile oil.

[0051] The volatile oil of the obtained Ginger Leaf Panax notoginseng was detected, and the result of the component content: 3,6,7,8-tetrahydro-3,3,6,6-tetramethylcyclopentadieno[E]indene-1(2H) - 24% for ketone, 15% for camphene; 12% for 1,7,7-trimethyl-bicyclo[2.2.1] hept-2-ketone, 3% for myrcene; 3% for caryophyllene oxide 2%.

Embodiment 2

[0052] Embodiment 2: ginger leaf notoginseng volatile oil

[0053] Take 150 g of fresh ginger leaf Sanqi rhizome and grind it, add 750 ml of distilled water to soak for 1 hour, extract by steam distillation for 4 hours, collect the essential oil in the upper layer, and obtain 2.2 ml of ginger leaf Sanqi volatile oil composition.

[0054] The volatile oil of the obtained Ginger Leaf Panax notoginseng was detected, and the result of the component content: 3,6,7,8-tetrahydro-3,3,6,6-tetramethylcyclopentadieno[E]indene-1(2H) -28% for ketone, 11% for camphene; 8% for 1,7,7-trimethyl-bicyclo[2.2.1]hept-2-ketone, 6% for myrcene; 6% for caryophyllene oxide 5%.

Embodiment 3

[0055] Embodiment 3: ginger leaf notoginseng volatile oil

[0056] Take 150 g of dried rhizome of Ginger-leaf Sanqi and grind it, add 1050 ml of distilled water to soak for 3 hours, extract by steam distillation for 6 hours, collect the essential oil in the upper layer, and obtain 2.0 ml of ginger-leaf Sanqi volatile oil composition.

[0057] The volatile oil of the obtained Ginger Leaf Panax notoginseng was detected, and the result of the component content: 3,6,7,8-tetrahydro-3,3,6,6-tetramethylcyclopentadieno[E]indene-1(2H) -30% for ketone, 20% for camphene; 15% for 1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ketone, 2% for myrcene; 2% for caryophyllene oxide 1%.

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Abstract

The invention relates to the new application of a stahlianthus involucratus, an extractive of the stahlianthus involucratus, a fat-soluble extractive of the stahlianthus involucratus and an essential oil composition of the stahlianthus involucratus, namely the new application of the stahlianthus involucratus, the extractive of the stahlianthus involucratus, the fat-soluble extractive of the stahlianthus involucratus and the essential oil composition of the stahlianthus involucratus in preparing drugs for treating and / or preventing liver cancer.

Description

technical field [0001] The present invention relates to new uses of ginger leaf notoginseng, ginger leaf notoginseng extract, ginger leaf notoginseng fat-soluble extract and ginger leaf notoginseng volatile oil, that is, new uses in preparing medicines for treating and / or preventing liver cancer. Background technique [0002] Liver cancer refers to malignant tumors that occur in the liver, including primary liver cancer and metastatic liver cancer. People usually refer to primary liver cancer when they say liver cancer. Primary liver cancer is one of the most common malignant tumors in clinical practice. According to the latest statistics, there are about 600,000 new liver cancer patients in the world every year, ranking fifth among malignant tumors. According to cell type, primary liver cancer can be divided into hepatocellular carcinoma, cholangiocellular carcinoma and mixed liver carcinoma. [0003] A large number of studies have confirmed that tumors are a type of cell ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61K31/336A61P35/00A61K125/00A61K31/125A61K31/12
Inventor 徐勤邓立东王芳蒋受军刘布鸣
Owner GUILIN MEDICAL UNIVERSITY