Suction-type ambroxol hydrochloride solution

A technology of ambroxol hydrochloride and solution, which is applied in the field of medicine, can solve the problems of lack of effective evidence for the safety of the respiratory system, lack of uniform standards for drug concentration and course of treatment, and lack of uniform standards for preparation concentration and course of treatment, etc., to improve drug absorption High efficiency, good expectoration effect, and less adverse reactions

Active Publication Date: 2013-12-25
赛隆药业集团股份有限公司
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ambroxol hydrochloride injection directly replaces the atomized inhalation solution dosage form to carry out atomization treatment, and there are many problems as follows: first, lack the uniform standard of drug concentration and course of treatment, clinically use ambroxol hydrochloride injection dosage form to carry out the preparation concentration of atomization inhalation treatment There is no unified standard for the course o

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Suction-type ambroxol hydrochloride solution
  • Suction-type ambroxol hydrochloride solution
  • Suction-type ambroxol hydrochloride solution

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0022] Example 1:

[0023] Add 15g ambroxol hydrochloride to 5000ml water for injection, stir to dissolve, add 0.5g sodium sulfite, 0.5g benzoic acid, 0.75g tetrabutyl phenolic aldehyde, dissolve completely, add appropriate amount of phosphate to adjust the pH value, then add appropriate amount of water for injection to make the solution system To 10000mL, then filter with a microporous membrane and dispense into medical control bottles. Each bottle is divided into 10mL. Each bottle of ambroxol hydrochloride has a concentration of 1.5mg / mL and a pH of 4.6.

Example Embodiment

[0024] Example 2:

[0025] Add 30g ambroxol hydrochloride to 6000mL physiological saline, stir to dissolve, add 0.8g gallic acid, 0.8g sorbic acid, 1.5g povidone, dissolve completely, add appropriate amount of hydrogen phosphate to adjust the pH value, then add appropriate amount of physiological saline to make The solution system is to 10000mL, and then filtered by a microporous membrane, and divided into medical control bottles, each 5mL, each bottle of ambroxol hydrochloride concentration is 3mg / mL, pH value is 5.8.

Example Embodiment

[0026] Example 3:

[0027] 20g ambroxol hydrochloride, add 6000mL isotonic glucose solution, stir to dissolve, add 0.3g sodium sulfite and 0.5g ascorbic acid, 0.6g peppermint oil, 1g polyethylene glycol, dissolve completely, add appropriate amount of sodium acetate to adjust the pH, then add Use appropriate amount of water for injection to make the solution system up to 10000mL, then filter with a microporous membrane, and dispense into medical control bottles. Each bottle is divided into 8mL. Each bottle of ambroxol hydrochloride has a concentration of 2mg / mL and a pH of 5.1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a suction-type ambroxol hydrochloride solution. The suction-type ambroxol hydrochloride solution is characterized in that per 100 mL of menstruum contains 0.15-0.3 g of ambroxol hydrochloride, a surface active agent accounting for 4-6 percent of the ambroxol hydrochloride in mass and a right amount of antioxidant and antiseptic; the pH value of the solution is 4.6-5.8; the menstruum is selected from water for injection, physiological saline and isotonic glucose solution. The suction-type ambroxol hydrochloride solution is sprayed into a patient's mouth, forms mist, directly enters a respiratory tract, is high in suction rate and local condition, realizes the safe and target treatment purpose, and effectively prompts the patient's phlegm to be discharged. Moreover, the suction-type ambroxol hydrochloride solution is low in use amount, high in medical effect, safe, good in stability, low in probability of pollution or oxidative deterioration and long in shelf life.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to an ambroxol hydrochloride solution for inhalation. Background technique [0002] Ambroxol hydrochloride is a new generation of respiratory mucus regulator, used for expectorant and cough. The source of ambroxol hydrochloride is Indian natural herbal duckbill flower, and the duckbill flower alkaloid extracted from duckbill flower is molecularly modified to obtain ambroxol hydrochloride. Ambroxol hydrochloride dosage forms listed at home and abroad include oral solutions, tablets, capsules, sustained-release capsules, injections, and freeze-dried powder injections for injection. The administration methods of these dosage forms are oral or injection administration. Injection and oral dosage forms have systemic effects, large adverse reactions, low utilization rate, and even bring certain pain and inconvenience to patients. [0003] The solution for inhalation is sprayed into the mou...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/72A61K31/137A61P11/14A61P11/10
Inventor 李剑峰
Owner 赛隆药业集团股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap