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The application of kits and rffl for assessing the prognosis of hepatocellular carcinoma

A kit and liver cancer technology, applied in the field of biomedicine, can solve the problem of lack of effective biological molecular markers in the prognosis assessment of hepatocellular carcinoma, and achieve the effect of accurate assessment of survival prognosis

Inactive Publication Date: 2016-06-15
THE FOURTH AFFILIATED HOSPITAL OF ZHEJIANG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to provide a kit for evaluating the prognosis of hepatocellular carcinoma and the application of RFFL, so as to solve the technical problem in the prior art that there are no effective biological molecular markers for evaluating the prognosis of hepatocellular carcinoma

Method used

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  • The application of kits and rffl for assessing the prognosis of hepatocellular carcinoma
  • The application of kits and rffl for assessing the prognosis of hepatocellular carcinoma
  • The application of kits and rffl for assessing the prognosis of hepatocellular carcinoma

Examples

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Embodiment 1

[0071] Using the present invention to analyze the prognosis of 30 cases of hepatocellular carcinoma patients, combined with the clinical follow-up study, the survival time and recurrence and metastasis data of the hepatocellular carcinoma patients after operation are obtained. According to the results of RFFL immunohistochemical MichioShimizu score, 30 cases of liver cancer specimens were divided into RFFL high expression group (positive expression group) and RFFL low expression group (negative expression group). The Kaplan-Meier survival curve method was used to calculate and analyze the postoperative survival of patients in the RFFL high expression group and low expression group, and the Log-rank method was used to compare and test the difference in overall survival between the two groups. The results showed that the overall survival rate of liver cancer patients in the RFFL high expression group was significantly lower than that in the RFFL low expression group ( P Figure ...

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Abstract

The invention discloses a kit for evaluating HCC prognosis and an application of RFFL. The kit comprises an agent used for specific detection of the RFFL expression level or expression pattern. With the application of the technical scheme, the kit is applied to detection of expression conditions of the RFFL in a tissue sample of an HCC patient, and the survival prognosis conditions of the HCC patient can be effectively and accurately evaluated.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a kit for evaluating the prognosis of hepatocellular carcinoma and the application of RFFL. Background technique [0002] Hepatocellular carcinoma (Hepatocellular carcinoma, HCC) is one of the most common malignant tumors in the world, the incidence rate ranks fifth among malignant tumors, and it is the second leading cause of cancer death. According to statistics, the number of deaths from liver cancer in my country accounts for about 50% of the global death toll due to liver cancer. At present, surgical treatment represented by hepatectomy is still the first choice for the treatment of liver cancer, but the recurrence and metastasis rate after 5 years is as high as 60%, or even higher. With the continuous improvement of liver surgery techniques, anesthesia and perioperative management, the surgical resection rate of liver cancer has been significantly increased, and the mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68G01N33/574
CPCC12Q1/6886C12Q2600/118C12Q2600/158G01N33/57438
Inventor 徐江锋刘细玉
Owner THE FOURTH AFFILIATED HOSPITAL OF ZHEJIANG UNIV SCHOOL OF MEDICINE