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Chitosan biological film-forming glue and preparation method thereof

A technology of chitosan and film-forming glue, applied in medical science, bandages, absorbent pads, etc., can solve the problems of poor solubility and limited application of chitosan, achieve high solubility, prevent excessive loss of water and body fluids, and biological good compatibility

Active Publication Date: 2014-12-24
GUANGXI XINYE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are many kinds of antibacterial dressings based on chitosan, but the solubility of chitosan in water is extremely poor, which greatly limits its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] A kind of chitosan biofilm-forming glue, comprises the raw material of following percentage by weight:

[0066] Modified Chitosan 0.5%

[0067] Mint 0.01%

[0068] Acidifier 0.05%

[0069] Skullcap 0.2%

[0070] Cork 0.1%

[0071] Deionized water balance.

[0072] The modified chitosan is chitosan hydrochloride with a degree of deacetylation of 70%.

[0073] The acidulant is lactic acid with a relative density of 1.20 and a lactic anhydride content of 5%.

[0074] A preparation method of chitosan biofilm-forming glue, comprising the steps of:

[0075] A. Add deionized water with 1 / 2 of the total amount of deionized water in the container, add the modified chitosan in the above ratio under stirring, and stir until completely dissolved;

[0076] B, add other raw materials except the modified chitosan of above-mentioned proportioning, acidulant under stirring state, vacuum filter after continuing to stir 5min, obtain filter residue and filtrate;

[0077] C, add the...

Embodiment 2

[0081] A kind of chitosan biofilm-forming glue, comprises the raw material of following percentage by weight:

[0082] Modified Chitosan 2.5%

[0083] Mint 0.04%

[0084] Acidifier 0.08%

[0085] Skullcap 0.25%

[0086] Cork 0.15%

[0087] Deionized water balance.

[0088] The modified chitosan is carboxymethyl chitosan with a carboxylation degree of 90%.

[0089] The acidulant is lactic acid with a relative density of 1.21 and a lactic anhydride content of 10%.

[0090] A preparation method of chitosan biofilm-forming glue, comprising the steps of:

[0091] A. Add deionized water with 2 / 3 of the total amount of deionized water in the container, add the modified chitosan in the above ratio under stirring, and stir until completely dissolved;

[0092] B, add other raw materials except the modified chitosan of above-mentioned proportioning, acidulant under stirring state, vacuum filter after continuing to stir for 6min, obtain filter residue and filtrate;

[0093] C, add...

Embodiment 3

[0097] A kind of chitosan biofilm-forming glue, comprises the raw material of following percentage by weight:

[0098] Modified Chitosan 3%

[0099] Mint 0.08%

[0100] Acidifier 0.1%

[0101] Skullcap 0.3%

[0102] Cork 0.2%

[0103] Deionized water balance.

[0104] The modified chitosan is a mixture of chitosan hydrochloride with a degree of deacetylation of 80% and carboxymethyl chitosan with a degree of carboxylation of 85%. Chitosan hydrochloride and carboxymethyl The weight ratio of chitosan is 2.5:1.

[0105] The acidulant is lactic acid with a relative density of 1.22 and a lactic anhydride content of 15%.

[0106] A preparation method of chitosan biofilm-forming glue, comprising the steps of:

[0107] A. Add deionized water with 1 / 2 of the total amount of deionized water in the container, add the modified chitosan in the above ratio under stirring, and stir until completely dissolved;

[0108] B, add other raw materials except the modified chitosan of above-m...

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Abstract

The invention relates to an external spray type antibacterial liquid dressing, and particularly relates to chitosan biological film-forming glue and a preparation method thereof. The chitosan biological film-forming glue comprises the following raw materials in percentage by weight: 0.5%-6% of modified chitosan, 0.01%-0.15% of mint, 0.01%-0.15% of acidifying agents, 0.2%-0.4% of radix scutellariae, 0.1%-0.3% of phellodendron and the balance of deionized water. The chitosan biological film-forming glue disclosed by the invention is prepared into a solution by adopting the modified chitosan, thereby keeping the self physicochemical characteristics and function roles of the chitosan and achieving good solubility property. The chitosan biological film-forming glue disclosed by the invention has good biocompatibility, multiple unique functions, namely higher solubility, easiness for organism absorption, and the like which do not exist in general chitosan, and well utilizes the biological activity of the chitosan.

Description

technical field [0001] The invention relates to an external spray type antibacterial liquid dressing, in particular to a chitosan biofilm-forming glue and a preparation method thereof. Background technique [0002] With the proposal of the theory of moist wound healing, various new dressings have emerged. According to incomplete statistics, there are more than 2,400 wound dressings currently on the market. How to choose the safest, economical and effective dressing according to the patient's wound condition and economic affordability is a problem often faced by Chinese medical staff in clinical work. Scholars at home and abroad have done a lot of research on dressing selection and application, but there is no consensus yet. Referring to the clinical effect research and related guidelines of dressings at home and abroad, the characteristics and clinical application of various products are described, in order to provide a basis for the rational selection of wound dressings i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/44
Inventor 梁奕福
Owner GUANGXI XINYE BIOLOGICAL TECH
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