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Preparation method and application of tranquilizing tablets

An Anshen Tablets, extraction technology, applied in the field of preparation of Anshen Tablets, can solve the problems of large doses of patients, affect the application, and many impurities, and achieve the effect of no bitterness in the dosage, reduced dosage, and easy to accept

Inactive Publication Date: 2014-02-12
姚晔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report about the use of supercritical and microwave technology in the extraction and preparation of Anshen Capsules. However, the method of directly powdering the medicine, impregnating and percolating, and decocting in water has rough and backward technology and many impurities, resulting in excessive dosage for patients. , it is inconvenient to take, seriously affecting the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take fried Suanzaoren 40g, Chuanxiong 47g, Anemarrhena 112g, Ophiopogon japonicus 92g, Polygonum multiflorum 32g, Schisandra 97g, Salvia miltiorrhiza 130g, Poria cocos 97g, add fried Suanzaoren and Schisandra to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 1.6L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 700W, and the extraction is performed twice. , 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under r...

Embodiment 2

[0034] Take fried Suanzaoren 40g, Chuanxiong 47g, Anemarrhena 112g, Ophiopogon japonicus 92g, Polygonum multiflorum 32g, Schisandra 97g, Salvia miltiorrhiza 130g, Poria cocos 97g, add fried Suanzaoren and Schisandra to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 1.6L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. , 5 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol und...

Embodiment 3

[0037] Take fried Suanzaoren 40g, Chuanxiong 47g, Anemarrhena 112g, Ophiopogon japonicus 92g, Polygonum multiflorum 32g, Schisandra 97g, Salvia miltiorrhiza 130g, Poria cocos 97g, add fried Suanzaoren and Schisandra to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 220min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 1.6L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 800W, and the extraction is performed twice. , 10 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol un...

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method and application of tranquilizing tablets. The tranquilizing tablets are prepared by adopting 40g of fried spina date seed, 47g of ligusticum wallichii, 112g of rhizoma anemarrhenae, 92g of radix ophiopogonis, 32g of prepared polygonum multiflorum, 97g of schisandra chinensis, 130g of salvia miltiorrhiza, 97g of poria as crude drugs and adopting supercritical extraction and microwave extraction, so that the content of schizandrin is greatly increased. The invention also provides application of the tranquilizing tablets in preparation of a medicament for inhibiting cell proliferation of myeloma cell SP2 / 0 of mice.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method and application of Anshen tablets. Background technique [0002] Anshen Capsules is recorded on page 717 of the Chinese Pharmacopoeia 2010 Edition. Nourishing blood and nourishing yin, nourishing the heart and calming the nerves. For deficiency of yin and blood, insomnia, dreaminess, palpitation and restlessness, dysphoria and fever, night sweat and tinnitus. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Anshen Capsules. However, the method of directly powdering the drug, impregnating and percolating, and decocting in water has rough and backward technology and many impurities, resulting in excessive dosage for patients. , inconvenient to take, has seriously affected the clinical application of this product. Contents of the invention...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/20A61P25/20A61P1/14A61P35/00
Inventor 姚晔
Owner 姚晔