Tiamulin soluble powder and preparation method thereof

A technology of soluble powder and tiamulin, which is applied in the direction of antibacterial drugs, powder delivery, respiratory diseases, etc., to achieve the effect of simple use, simple method and stable storage

Inactive Publication Date: 2014-02-19
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] An object of the present invention is to provide tiamulin soluble powder to overcome the defects of existing tiamulin dosage forms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Tiamulin soluble powder, which mainly uses tiamulin and citric acid as the main ingredients, with appropriate amount of spices, soluble flavoring agents and soluble fillers, after drying, weighing, crushing, stirring, warming, It is prepared by conventional methods such as inspection, measurement, and packaging.

[0025] Recipe and method:

[0026] Tiamulin 22g

[0027] Citric Acid 5 g

[0028] Cinnamon spice 0.1 g

[0029] Glucose balance.

[0030] production method

[0031] (1) above-mentioned raw material is dried, make its water content less than 5%;

[0032] (2) Weighing, the raw materials of the above components are fully pulverized, and sieved through a 40 to 60 mesh sieve;

[0033] (3) Pour the sieved raw materials and auxiliary materials into the V-type mixer, stir them thoroughly for 30 minutes, and mix them evenly;

[0034] (4) Sampling and testing to check the percentage of raw material content, whether the fineness of the powder meets the standard, ...

Embodiment 2

[0037] The tiamulin soluble powder described in this embodiment contains 6% tiamulin and 3% citric acid. Dry 7.5 grams of tiamulin, 4 grams of citric acid, 1 gram of cinnamon spice, and 57.5 grams of sucrose so that the water content is less than 5%, weigh them, thoroughly pulverize the raw materials of the above components, and use 40 to 60 mesh Sieve for sieving. Pour the sieved above-mentioned raw materials and 57.5 grams of glucose into a V-shaped mixer, stir thoroughly for 30 minutes, and mix well.

[0038] Sampling and testing to check the percentage of raw material content, whether the fineness of the powder meets the standard, whether the water content is qualified, etc., measure and weigh, pack into bags, and put 5 grams, 10 grams or 100 grams of the above powder in each bag to obtain Tiamulin Vegetarian soluble powder.

[0039] Sampling and testing to check the percentage of raw material content, whether the fineness of the powder meets the standard, whether the wa...

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PUM

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Abstract

The invention discloses tiamulin soluble powder. The tiamulin soluble powder comprises the following raw materials by weight: 3.0-25.0% of tiamulin, 2.0-16.0% of cosolvent, 0.1-1.2% of spice, 1.0-21.0% of a soluble flavoring agent, and the balance of soluble filler. The invention further discloses a preparation method of the tiamulin soluble powder. Tests prove that the tiamulin soluble powder has the characteristics such as simple application, low cost, full fragrance, stable storage, convenience in transport and good water solubility, largely improves the curative effect of the tiamulin, and is novel, broad-spectrum and efficient special powder injection for animals.

Description

technical field [0001] The invention belongs to the technical field of veterinary antibiotic drugs, and in particular relates to tiamulin soluble powder and a preparation method thereof. Background technique [0002] Tiamulin is a kind of diterpene-type livestock and poultry special-purpose antibiotic, which is fermented by the higher fungus Pleurotus mutilus to obtain pleuromutilin and then chemically synthesized to obtain hydrogenated fumarate. It was first proposed by Kavangh in Australia in 1951 and extensively studied in the 1960s. It is one of the top ten veterinary antibiotics in the world. Its molecular formula is C 28 h 47 N0 4 S·C 4 h 4 0 4 , melting point is 143 ~ 149 ℃, easily soluble in methanol or ethanol, soluble in water, slightly soluble in acetone, almost insoluble in ethane. The antibacterial spectrum is similar to that of macrolide antibiotics, mainly against Gram-positive bacteria, and has strong inhibitory effects on Staphylococcus aureus, Strep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/22A61P31/04A61P11/00
Inventor 不公告发明人
Owner QINGDAO AGRI UNIV
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