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Preparation method and application of Aleuritopteris argentea Fee extract

A technology of extracts of Herba Tongjing, applied in the preparation of drugs for the prevention and treatment of diabetes, the preparation of extracts from Chinese herbal medicines, and the field of preparation of Herba Tongjing extracts, which can solve the problems that have not yet been seen Preparation of extracts to prevent and treat diabetes drug reports and other issues, to achieve the effect of low production cost, high safety and definite curative effect

Inactive Publication Date: 2014-02-19
王珊 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned documents and patents, etc., have not yet seen the report of Tongjingcao or Tongjingcao extract being used to prepare drugs for the prevention and treatment of diabetes

Method used

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  • Preparation method and application of Aleuritopteris argentea Fee extract
  • Preparation method and application of Aleuritopteris argentea Fee extract
  • Preparation method and application of Aleuritopteris argentea Fee extract

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1: Preparation of Tongjingcao Extract and Monomer Compounds

[0029] Put 20kg of Herbs japonica into the extraction tank, add 10 times the amount of 70% ethanol, extract twice at 70°C for 1 hour each time, combine the extracts, recover the ethanol, filter, combine the extracts, recover the ethanol, concentrate, dry, Obtain 100 g of Herbs’ Herbs Extract A6; dissolve 100 g of Herbs’ Herbs’ Extract A6 in 20 times the amount of water, and filter to obtain liquid A and precipitate A. The precipitate A was separated and purified by high-speed countercurrent chromatography (HSCCC) with n-hexane-ethyl acetate-methanol-water (2:2:3:2) as the solvent system, the solvent was recovered, concentrated and dried, and the general Herbal extract B250g; drug solution A, pass through HPD600 macroporous adsorption resin column, elute 2BV (resin column volume) with water, and then use ethanol solution with a concentration of 10-70% for gradient elution, and collect ethanol eluents w...

Embodiment 2

[0032] Example 2: Preparation of Tongjingcao Extract and Monomer Compounds

[0033] (1) Put 2 kg of Herba Trichonia into an extraction tank, use water as a solvent, and extract by warm soaking at 80°C. The number of extractions is 1 time, and the extraction time is 4 hours. The amount of solvent used each time is 15 times the weight of the medicinal material; filter, Combine the extracts, concentrate, and dry to obtain the extract A of Tongjingcao;

[0034] (2) Add 5 times the amount of water to dissolve the extract A obtained in step (1), and filter to obtain medicinal solution A and precipitate A. The precipitate A was separated and purified by high-speed countercurrent chromatography (HSCCC) with n-hexane-ethyl acetate-methanol-water (2:2:3:2) as the solvent system, the solvent was recovered, concentrated and dried, and the general Herbal Extract B;

[0035] (3) Pass the drug solution A obtained in step (2) through the NKA macroporous adsorption resin column, elute with w...

Embodiment 3

[0039] Example 3: Preparation of Tongjingcao Extract and Monomer Compounds

[0040] (1) Put 5 kg of Herbs through the extraction tank, use a concentration of 90% as a solvent, and extract by warm soaking at 20°C. The number of extractions is 3 times, and the extraction time for each time is 1 hour. The amount of solvent used each time is the weight of the medicinal material. 6 times; filter, combine the extracts, recover ethanol, concentrate, dry, and get the extract A of Tongjingcao;

[0041] (2) Add 20 times the amount of water to dissolve the extract A obtained in step (1), and filter to obtain medicinal solution A and precipitate A. The precipitate A was separated and purified by high-speed countercurrent chromatography (HSCCC) with n-hexane-ethyl acetate-methanol-water (2:2:3:2) as the solvent system, the solvent was recovered, concentrated and dried, and the general Herbal Extract B;

[0042] (3) Pass the drug solution A obtained in step (2) through an AB-8 macroporous...

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Abstract

The invention relates to a preparation method and application of an Aleuritopteris argentea Fee extract. The preparation method includes: extracting Aleuritopteris argentea Fee, then performing high-speed counter-current chromatography, macroporous adsorption resin and other chromatography purification to obtain an Aleuritopteris argentea Fee extract B and an Aleuritopteris argentea Fee extract C, mixing the Aleuritopteris argentea Fee extract B with the Aleuritopteris argentea Fee extract C in certain proportion, thus obtaining the Aleuritopteris argentea Fee extract, which can be combined with a pharmaceutically acceptable carrier or other suitable excipients so as to be prepared into oral medication dosage forms according to conventional methods. The Aleuritopteris argentea Fee extract can be used for preparing drugs for preventing and treating diabetes.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a preparation method and application of an extract of Chinese medicinal materials, in particular to a preparation method of an extract of Tongjingcao and its application in the preparation of drugs for preventing and treating diabetes. Background technique [0002] With the aging of the world's population, diabetes has become a common and frequently-occurring disease, and its incidence is on the rise in industrialized countries. According to statistics, there are about 150 million diabetic patients in the world, 80% of which are non-insulin-dependent diabetes (type 2), of which there are about 30 million in my country. The number of deaths caused by diabetes complications ranks third after cardiovascular and cerebrovascular diseases and cancer in developed countries, which has attracted great attention from all over the world, and researches on the pathogenesis and drug prevention and tr...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61P3/10
Inventor 孔倩倩
Owner 王珊
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