Application of carbohydrates in the preparation of medicines for treating platelet count-related diseases

A platelet and quantity technology, applied in blood diseases, drug combinations, allergic diseases, etc., can solve problems such as the application of carbohydrate drugs that have not been reported yet, and achieve the effects of low cost, broad clinical application prospects and good curative effect.
CN103610684BActive Publication Date: 2016-04-06SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2016-04-06

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Abstract

The invention discloses an application of saccharides in preparing a medicament for treating platelet quantity related diseases. Saccharides can be one or more of monosaccharides, oxidation-reduction derivatives of the monosaccharides, oligosaccharides, polysaccharides, composite polysaccharides and glycosides. Platelet quantity related diseases comprise primary or secondary thrombocytosis, and primary or secondary thrombocytopenia. Experiments discover that the antibody at an antiplatelet GPIb (glycoprotein Ib) alpha N terminal can induce activation and death of platelets, the platelets can be quickly removed in liver by macrophagocyte, while the saccharides can remarkably inhibit platelet removal caused by the platelet GPIb alpha antibody, and the platelet quantity can be regulated. The application of the saccharides in preparing the medicament for treating platelet quantity related diseases is provided for the first time, and the novel application of the saccharides is expanded.
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Description

technical field

[0001] The invention relates to the field of biopharmaceuticals, in particular to the application of carbohydrates in the preparation of medicines for treating diseases related to the number of platelets. Background technique

[0002] Clinically, abnormal platelet counts caused by various factors can cause related diseases, such as primary or secondary thrombocytosis, primary or secondary thrombocytopenia, including immune thrombocytopenia, etc. Thrombocytosis is a myeloproliferative disorder characterized by abnormal hyperplasia of unknown cause accompanied by persistent increase of platelets. Thrombosis, splenomegaly, and platelet persistence increased significantly, and the etiology was unknown. The bleeding mechanism of this disease may be related to platelet dysfunction or enhanced fibrinolysis. According to the epidemiological survey of essential thrombocythemia in 5 European and American countries, the incidence rate is 0.59 / 100,000 to 2.53 / 100,000, ...

Claims

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