Preparation method for self-skull used in replantation technology

A production method and skull technology, applied in the field of preparation of autologous skull replantation technology, can solve the problems of affecting appearance, easy deformation, trauma and infection, etc., and achieve the effect of rich foam, reducing antigenicity and strong detergency

Inactive Publication Date: 2014-03-12
胡晓予 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past 10 years, most of the cranial defect repair materials recognized by clinicians are medical titanium mesh, but titanium mesh also has shortcomings that make patients and doctors unsatisfied, for example: heat conduction can cause headaches and even epilepsy, and it is easy to deform and affect the appearance , MRI examinations are also affected to varying degrees
[0003] Many years ago, some scholars buried the autologous skull in the patient's own body (such as the inner thigh, abdomen, etc.), and when it was taken out for use after a few months, autologous bone resorption occurred, making it impossible to repair the original defect. Of course, burying the autologous skull elsewhere in the autologous body presents the risk of new trauma and infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, a preparation method of autologous skull replantation technology of the present invention, it adopts the following steps to make;

[0020] (1) Decontamination process: Use ordinary detergent to clean the oil and other impurities on the surface of the bone, then rinse it with distilled water, and dry it to obtain a complete autologous skull matrix.

[0021] (2) Virus inactivation process: at room temperature, use peracetic acid-ethanol mixture composed of 10g / L peracetic acid and 24% ethanol by volume fraction, and immerse the autologous skull matrix for 4-6 hours with microwave vibration.

[0022] (3) Deproteinization process: at room temperature, put the autologous skull matrix into 15% hydrogen peroxide H 2 o 2 Soak in a medium microwave for 60 hours, then rinse with purified water.

[0023] (4) Degreasing process: use 95% alcohol, ether, and wash to soak, degrease and rinse with purified water, put the autologous skull matrix into a centrifuge for deh...

Embodiment 2

[0030] Embodiment 2, a method for making an acellular matrix autologous skull of the present invention, which is made by the following steps;

[0031] (1) Decontamination process: Use ordinary detergent to clean the oil and other impurities on the surface of the bone, then rinse it with distilled water, and dry it to obtain a complete autologous skull matrix.

[0032] (2) Virus inactivation process: at room temperature, use peracetic acid-ethanol mixture composed of 10g / L peracetic acid and 24% ethanol by volume fraction, and immerse the autologous skull matrix for 4-6 hours with microwave vibration.

[0033] (3) Deproteinization process: at room temperature, put the autologous skull matrix into 18% hydrogen peroxide H 2 o 2 Soak in a medium microwave for 55 hours, then rinse with purified water.

[0034] (4) Degreasing process: use 95% alcohol, ether, and wash to soak, degrease and rinse with purified water, put the autologous skull matrix into a centrifuge for dehydration,...

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PUM

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Abstract

A disclosed preparation method for self-skull used in replantation technology comprises that the self-skull is obtained for replantation by performing decontamination, pathogen inactivation, deproteinization, degreasing, decellularization, freeze drying, disinfection and the like on self skull taken out after an operation. The preparation method has the advantages that the storage time is long, the appearance of the taken-out self-skull is not changed after the self-skull is processed, no rejection phenomenon exists after implantation, and the like.

Description

technical field [0001] The invention relates to a preparation method of autogenous skull replantation technology. Background technique [0002] Bone repair has always been a clinical problem, especially decompressive craniectomy for neurosurgery is an effective treatment for patients with traumatic brain injury / cerebral hemorrhage. In order to achieve the purpose of surgical decompression, the resected bone flap cannot be restored , Therefore, the operation caused most patients with skull defects. Usually, in order to reduce the side effects caused by the skull defect to the patient, the doctor advises the patient to return to the hospital for repair of the skull defect after about 3 months. In the past 10 years, most of the cranial defect repair materials recognized by clinicians are medical titanium mesh, but titanium mesh also has shortcomings that make patients and doctors unsatisfied, for example: heat conduction can cause headaches and even epilepsy, and it is easy to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36
Inventor 胡晓予黄楹刘勇
Owner 胡晓予
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