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Content determination method of traditional Chinese medicine composition

A determination method and composition technology, which can be applied to measurement devices, instruments, scientific instruments, etc., can solve problems such as failure to fully reflect the quality of preparations, and achieve the effect of simple methods

Active Publication Date: 2014-03-26
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The standards of most traditional Chinese medicines only quantitatively analyze a single index component, which fails to fully reflect the quality of the preparation

Method used

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  • Content determination method of traditional Chinese medicine composition
  • Content determination method of traditional Chinese medicine composition
  • Content determination method of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0121] In order to facilitate the implementation of the method for determining the content of the Chinese medicine composition, the Chinese medicine composition is prepared as a tablet

[0122] prescription:

[0123] Houttuynia cordata 833g, honeysuckle flower 833g, red peony root 500g, mugwort leaf 333g, mint 167g

[0124] Preparation:

[0125] Take honeysuckle and add 12 times the amount of 50% ethanol, reflux extraction twice, each time for 0.5 hours, filter the extract, combine the filtrate, recover ethanol under reduced pressure and concentrate, dry under reduced pressure, pulverize to obtain extract powder I; Houttuynia cordata , mugwort leaves, peppermint, add 8 times the amount of water, steam distillation to extract the volatile oil for 5.0 hours, collect the volatile oil, and set aside; release the medicinal liquid, collect it in another device, add 10 times the amount of water to the dregs and red peony root, decoct twice, each time After 1.0 hour, the decoction w...

Embodiment 2

[0133] In order to facilitate the implementation of the method for determining the content of the Chinese medicine composition, the Chinese medicine composition is prepared as a drop pill

[0134] prescription:

[0135] Houttuynia cordata 18g, honeysuckle 18g, red peony 6g, mugwort leaves 6g, mint 3g

[0136] Preparation:

[0137] Take honeysuckle and add 12 times the amount of 50% ethanol, reflux extraction twice, each time for 0.5 hours, filter the extract, combine the filtrate, recover ethanol under reduced pressure and concentrate, dry under reduced pressure, pulverize to obtain extract powder I; Houttuynia cordata , mugwort leaves, peppermint, add 8 times the amount of water, steam distillation to extract the volatile oil for 5 hours, collect the volatile oil, and set aside; release the medicinal liquid, collect it in another device, add 10 times the amount of water to the dregs and red peony, decoct twice, each time After 1.0 hour, the decoction was combined with the a...

Embodiment 3

[0145] In order to facilitate the implementation of the method for determining the content of the Chinese medicine composition, the Chinese medicine composition is prepared as a hard capsule

[0146] prescription:

[0147] Houttuynia cordata 943g honeysuckle 808g red peony 540g mugwort 540g mint 270g

[0148] Preparation:

[0149]Take honeysuckle and add 12 times the amount of 50% ethanol, reflux extraction twice, each time for 0.5 hours, filter the extract, combine the filtrate, recover ethanol under reduced pressure and concentrate, dry under reduced pressure, pulverize to obtain extract powder I; Houttuynia cordata , mugwort leaves, peppermint, add 8 times the amount of water, steam distillation to extract the volatile oil for 5 hours, collect the volatile oil, and set aside; release the medicinal liquid, collect it in another device, add 10 times the amount of water to the dregs and red peony, decoct twice, each time After 1.0 hour, the decoction was combined with the ab...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and the invention discloses a content determination method of a traditional Chinese medicine composition. The method comprises (a) the preparation of a sample solution, (b) the preparation of a reference solution, (c) chromatographic conditions, to be more specific, a chromatographic column of C18 reversed phase chromatographic column, the column temperature of 30 DEG C, mobile phases of A acetonitrile and B trifluoroacetic acid solution, the gradient elution flow rate of 0.4ml / min, detection wavelengths of 230nm and 327nm, and (d) determination. The method is strong in specificity and simple in operation, and the quality of the traditional Chinese medicine composition can be effectively controlled.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a method for determining the content of a traditional Chinese medicine composition. The method uses ultra-high performance liquid chromatography to simultaneously measure the contents of chlorogenic acid and paeoniflorin. Background technique [0002] Traditional Chinese medicine is an outstanding historical and cultural treasure house of the Chinese nation, and it is the wisdom accumulated through thousands of years of clinical experience. According to statistics, my country has more than 90,000 prescriptions, more than 5,000 kinds of Chinese patent medicines, 43 kinds of Chinese medicine forms in 35 categories, and 12,807 kinds of medicinal materials. Traditional Chinese medicine is the main method of treating diseases in traditional Chinese medicine. The theory of traditional Chinese medicine emphasizes the overall effect of traditional Chinese medicine...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 萧伟王振中毕宇安闫明吴云孙永成李芳芳韦迎春李淼徐海娟
Owner JIANGSU KANION PHARMA CO LTD
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