Automatic Tracking Method of Temperature Place Preference Behavior of Experimental Rats

Abstract

The invention relates to an automatic tracking method of temperature place preference behaviors in laboratory mice. The method at least includes the steps: a laboratory mice temperature stimulation passage is divided into different temperature zones, each temperature zone is provided with a heating plate and a heating plate temperature sensor, each temperature zone is provided with temperature zone boundary left and right sensor bars, the heating plates are electrically connected with a processing unit through a heating control circuit, the processing unit is respectively connected with the heating plate temperature sensors, the boundary right sensor bars and the boundary left sensor bars through signal wires, the processing unit sets certain temperature spots for the different temperature zones through a human-machine interface, the processing unit controls heating through the heating control circuit, the temperatures of the corresponding temperature zones are controlled in the required temperature field accordingly, the temperature zone boundary of the different temperature zones is used for distinguishing a passing direction of the laboratory mouse through the boundary right sensor bars and the boundary left sensor bars, and the durations of the laboratory mouse being in the temperature zones at different times are provided according to recorded durations, and temperature preference behaviors of the laboratory mice are further understood.

Description

technical field [0001] The invention belongs to the automatic observation method of medical animal experimental behavior, in particular to the automatic tracking method of the thermal position preference behavior of experimental mice. Background technique [0002] Pain is an unpleasant sensory and emotional experience associated with potential and actual tissue damage. When animals are subjected to noxious stimuli under physiological conditions, they usually immediately produce a rapid avoidance or defensive response behavior, which is called acute pain response. Chronic pain models and pain behavioral detection methods. Others compare chronic pain to a cancer that never dies. Patients with chronic pain manifest spontaneous pain (spontaneous pain), hyperalgesia (hyperalgesia) and touch-induced pain (allodynia, also known as allodynia). Spontaneous pain, also known as ongoing pain, refers to the pain shown by the body without stimulation, and its pain properties are also...

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Problems solved by technology

[0004] Disadvantages of this measurement method: Measuring animal responses to stimuli at only two temperatures (15 and 45°C); During the observation process, the experimenter needs to record the time and the number of shuttles between the two compartments in real time, which will add a lot of extra work and introduce another subjective measurement error factor

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