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Implanted fibrous membrane for repairing pelvic floor dysfunctional disease, preparation method and medical device containing same

A technology for implanting medical devices and functional disorders, applied in the field of implanted diaphragms, preparations, and medical devices for the treatment of female pelvic floor dysfunction diseases, can solve problems such as unsatisfactory performance of fibrous membranes, and achieve favorable adhesion and proliferation. , reduce or avoid erosion, reduce shrinkage effect

Active Publication Date: 2016-12-21
MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the performance of fiber membranes for tissue repair formed by existing weaving or electrospinning techniques is not ideal

Method used

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  • Implanted fibrous membrane for repairing pelvic floor dysfunctional disease, preparation method and medical device containing same
  • Implanted fibrous membrane for repairing pelvic floor dysfunctional disease, preparation method and medical device containing same
  • Implanted fibrous membrane for repairing pelvic floor dysfunctional disease, preparation method and medical device containing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] (1) Dissolve polyvinylidene fluoride (PVDF) in a mixed solvent of N,N-dimethylformamide / acetone with a volume ratio of 4:6, so that the concentration of PVDF in the solution is 18g / 100mL to obtain a uniform Fiber material solution A; L-polylactic acid (PLLA) was dissolved in hexafluoroisopropanol (HFIP) solution, so that the concentration of PLLA in the solution was 5g / 100mL, and a uniform fiber material solution B was obtained.

[0131] (2) The above two homogeneous fiber material solutions A and B were filled into five electrospinning syringes respectively, among which 4 syringes were filled with PVDF solution and one syringe was filled with PLLA solution. 4 injection needles corresponding to PVDF solution and 1 injection needle corresponding to PLLA are evenly arranged on the high-voltage power supply board, adjust the rate of the micro-injection pump to 5mL / hour, adjust the voltage of the high-voltage generator to 30KV, and adjust the receiving distance of the receiv...

Embodiment 2

[0135] (1) Dissolve PVDF material in N,N-dimethylformamide / acetone mixed solvent with a volume ratio of 4:6, so that the concentration of PVDF in the solution is 20g / 100mL; prepare a uniform fiber material solution.

[0136] (2) Put the fiber material solution obtained in step (1) into the electrospinning syringe, adjust the rate of the micro-injection pump to 6mL / hour, adjust the voltage of the high-voltage generator to 30KV, and adjust the receiving distance of the receiving device to 25cm , electrospinning is carried out to obtain fiber filaments, and the fiber filaments are received into a film-like structure, and the electrospinning is stopped after spinning until the thickness of the film layer is about 0.5 mm to obtain a fiber film.

[0137] The fiber membrane obtained here has an average fiber diameter of 2 μm, a membrane thickness of 0.5 mm, an average pore diameter of 150 μm, a tensile strength of 32 N / cm, and a bulkiness of 110 cm 3 / g, the softness is 740 millinewt...

Embodiment 3

[0141] (1) Dissolve PVDF material in N,N-dimethylformamide / acetone mixed solvent with a volume ratio of 4:6, so that the concentration of PVDF in the solution is 18g / 100mL; prepare a uniform fiber material solution;

[0142] (2) Put the fiber material solution obtained in step (1) into the electrospinning syringe, adjust the rate of the micro-injection pump to 6mL / hour, adjust the voltage of the high-voltage generator to 30KV, and adjust the receiving distance of the receiving device to 20cm , electrospinning is carried out to obtain fiber filaments, and the fiber filaments are received into a film-like structure, and the electrospinning is stopped after spinning until the thickness of the film layer is about 0.5 mm to obtain a fiber film.

[0143] The fiber membrane obtained here has an average fiber diameter of 2 μm, a membrane thickness of 0.5 mm, an average pore diameter of 190 μm, a tensile strength of 43 N / cm, and a bulkiness of 170 cm 3 / g, the softness is 930 millinewt...

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Abstract

The invention provides an implantation fiber membrane used for female pelvic floor dysfunction tissue repair. The implantation fiber membrane is characterized by comprising a fluffy fibrous layer (A), wherein the fluffy fibrous layer (A) is formed by interweaving cellosilks with the diameters of 10 nanometers-100 micrometers, and is of a porous structure, the filling power is 400-1500 cm<3> / g, and the softness is 50-500 millinewton. Preferably, the implantation fiber membrane further comprises a directed fibrous layer (B), and the directed fibrous layer (B) is a layer which is formed by the directional alignment of the cellosilks and is of a porous three-dimensional structure.

Description

technical field [0001] The invention relates to an implanted diaphragm, in particular to an implanted diaphragm for treating female pelvic floor dysfunction diseases, a preparation method and a medical device containing the same. Background technique [0002] Affected by factors such as childbirth, disease, and aging, the soft tissue around the pelvic floor is weakened in supporting the pelvic organs, leading to various pelvic floor dysfunction diseases. Pelvic floor dysfunction is a common and frequently-occurring disease in women. Female pelvic floor dysfunction (Pelvic Floor Dysfunction disease, PFD), also known as pelvic floor defect or pelvic floor support tissue relaxation, mainly manifests as prolapse of pelvic organs (such as bladder, uterus, rectum, vagina and small intestine, etc.) Sagging, bulge (Pelvic OrganProlapse, POP) and stress urinary incontinence (Stress Urinary Incontinence, SUI). Both POP and SUI are closely related and have a serious impact on women's...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/02A61B17/00A61L27/50A61L27/54A61L27/40A61L27/18A61L27/20A61L27/22A61L27/24
Inventor 王国帅郭泽跃赖奎霖徐弢袁玉宇
Owner MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD
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