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Application of novonidocycin produced by Streptomyces phytophytes in the preparation of antitumor preparations

A technology of nivolomycin and Streptomyces phytogenes, applied in antitumor drugs, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as affecting the quality of life of patients

Active Publication Date: 2016-08-24
HUBEI BIOPESTICIDE ENG RES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the severe toxicity of chemotherapy drugs and the drug resistance of tumor cells have always affected the efficacy of drugs and the improvement of patients' quality of life.

Method used

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  • Application of novonidocycin produced by Streptomyces phytophytes in the preparation of antitumor preparations
  • Application of novonidocycin produced by Streptomyces phytophytes in the preparation of antitumor preparations
  • Application of novonidocycin produced by Streptomyces phytophytes in the preparation of antitumor preparations

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Experimental program
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Effect test

Embodiment Construction

[0021] Two new antibiotics produced by Streptomyces phytophytes, Novonestmycin A (Novonestmycin A) and Novonestmycin B (Novonestmycin B) have significant antitumor activity, and the results of in vitro antitumor activity assays show that these compounds It has strong inhibitory activity on a variety of human tumor cell lines (human liver tumor cell line HepG2, Bel-7402, human gastric cancer cell line BGC-823, human breast cancer cell line MCF-7), among which it is resistant to 5-fluorouracil tumor cells (Bel-7402) also showed good anti-tumor activity, stronger than the positive control drug paclitaxel, so it can be used to prepare anti-tumor preparations.

[0022] The test method of antitumor activity of novomycin is as follows:

[0023] (1) Novomycin sample preparation

[0024] Weigh 1mg of novomycin A or B sample, add 1ml DMSO (dimethyl sulfoxide) to prepare 1mg / ml novomycin A or B sample mother solution for future use. Then it was diluted to 10ppm with DMSO, and according...

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Abstract

The invention relates to the application of novonestmycin generated by streptomyces phytohabitans in the preparation of antitumor agents. Streptomyces phytohabitans of which the number is HBERC-20821 is used to generate two kinds of antibiotics which are respectively named novonestmycin A and novonestmycin B. The novonestmycin A and novonestmycin B have significant antitumor activities, and the measurement result of antitumor activity in vitro indicates that novonestmycin A and novonestmycin B have strong inhibitory activity to various human tumor cell lines such as human liver tumor cell lines HepG2, Bel-7402, human stomach cancer cell line BGC-823, human breast cancer cell line MCF-7, and have good antitumor activity to tumor cells Bel-7402 resistant to 5-fluorouracil, so that novonestmycin can be used for preparing antitumor agents.

Description

technical field [0001] The invention relates to the application of novonidocycin produced by streptomyces phytophytes in the preparation of antitumor preparations. Background technique [0002] The applicant has applied for "Streptomyces phytohabitans and its method and application for producing a new antibiotic novonidocycin" (Chinese patent application number 2013105526945), Streptomyces phytohabitans, strain code HBERC-20821, preserved in China Center for Type Culture Collection, Wuhan University, Wuhan, China, the deposit number is CCTCC NO: M2013379. The date of preservation is August 20, 2013, and the date of survival certificate is September 6, 2013. [0003] Two new antibiotics produced by Streptomyces phytophytes were named Novonestmycin A and Novonestmycin B respectively. [0004] Chemical structure of Novonestmycin A [0005] [0006] Chemical structure of Novonestmycin B [0007] [0008] Cancer is a frequently-occurring and common disease that seriousl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P35/00
Inventor 万中义杨自文王开梅方伟江爱兵石丽桥张亚妮张志刚闵勇刘晓艳曹春霞黄大野龙同吴兆圆廖先清刘芳张遵霞
Owner HUBEI BIOPESTICIDE ENG RES CENT