Arylnaphthyl lignans as anti-HIV agents

A technology of medicine and alkyl, applied in the field of derivatives of aryl naphthalene lignans, can solve the problem of not containing sugar units and the like

Active Publication Date: 2017-02-15
THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, none of the reported anti-HIV active arylnaphthyl lignans contain sugar units

Method used

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  • Arylnaphthyl lignans as anti-HIV agents
  • Arylnaphthyl lignans as anti-HIV agents
  • Arylnaphthyl lignans as anti-HIV agents

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Embodiment

[0144] Rhizome samples of Acucus spp. were collected from Cuc Phuong National Park (Nho Quan District, Ninh Binh Province, Vietnam). Its methanol extract exhibited potent inhibitory activity against HIV replication, and IC 50 The value is 0.04 μg / mL. A 4.0 kg dry bark sample of this plant was therefore recollected from a Vietnamese National Park to identify anti-HIV compounds. Thus, two novel (1 and 2) and one known (3) arylnaphthyl lignans were isolated from this plant by bioactivity-guided fractionation studies. In structures 1 and 2, Ac stands for acetyl (-COCH 3 ), and Glu represents β-D-glucopyranosyl.

[0145]

[0146] Another sample (4.0 kg) of the rhizome of Scutellaria baicalensis was taken using MeOH extraction to provide an extract (155 g). Isolation of two novel arylnaphthalenoid lignans, japonicamin, by bioactivity-guided fractionation of MeOH extracts by column chromatography on silica gel and RP-18 reversed-phase silica gel followed by preparative HPLC se...

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Abstract

Provided herein are glycosylarylnaphthalenoid lignan compounds, such as jupecumin A, isolated from the plant Justicia gendarussa Burm.f. (Acanthaceae) effective in the treatment of AIDS and HIV infection (justiprocumin A).

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application Serial No. 61 / 513,119, filed July 29, 2011, which is hereby incorporated by reference in its entirety. [0003] Statement Regarding Federally Funded Research [0004] This invention was made with Government support under Grant No. 1UO1-TW01015-01 from a National Institutes of Health grant administered by the Fogarty International Center. The US Government has certain rights in this invention. technical field [0005] The present invention relates to anti-HIV agents originally derived from natural sources. More specifically, the agents are derivatives of aryl naphthalide lignans. The object of the present invention is to provide aryl naphthalene lignan compounds having anti-HIV activity. Background technique [0006] Since it was first reported in the United States in 1981, AIDS has become a global epidemic. In UNAIDS (United World Against AIDS) ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D407/04C07H15/252A61K31/7028A61P31/18
CPCC07H17/04C07D407/04A61P31/18
Inventor 张宏杰D·苏扎多荣立军H·H·方E·鲁姆斯拉格-布姆斯
Owner THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
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