The invention relates to a medicinal extract for treating a bone disease, which comprises the following materials in parts by weight: Japanese ginseng, stiff silkworms, scarab, lumbricus, centipede, rhizoma gastrodiae, uncaria, peach kernel, carthamus tinctorius, rehmannia glutinosa, radix paeoniae alba, angelica sinensis, ligusticum wallichii, achyranthes bidentata, platycodon grandiflorum, liquorice, rhubarb, pseudobulbus cremastrae seu pleiones, paris polyphylla, fructus broussonetiae, peucedanum decursivum maxim, thlaspi arvense, smilax, chicory, rhizoma dioscoreae septemlobae, herba siegesbeckiae, justicia gendarussa, manchurian lilac bark, pterocephalus hookeri heck, nodus nelumbinis rhizomatis, medulla stachyuri, common bombax flower, concha arcae, Chinese mahonia stem, sauropus spatulifolius, white hyacinth bean, loofah sponge, perfoliote knotweed herb, feather cockscomb seeds, piper cubeba, tung oil and red lead. The invention further relates to a preparation method of the medicinal extract. The medicinal extract can be used for treating rheumatism numbness, arthritis, early scapulohumeral periarthritis pain, lumbar muscle degeneration, muscular soreness, traumatic injuries and the like.