dna typing method and kit for hla gene
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- GENODIVE PHARMA
- Publication Date
- 2016-08-17
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Abstract
Description
technical field
[0001] The invention relates to a method and a kit for using a large-scale parallel sequence analyzer to carry out DNA typing of HLA genes. Background technique
[0002] Human leukocyte antigen (HLA), which is the human major histocompatibility complex (MHC), is profoundly involved in the induction of immune responses by presenting to T cells peptides derived from foreign proteins such as pathogens as well as peptides derived from their own proteins, with 6 This antigen is known as the major HLA. That is, class I molecules (HLA-A, HLA-B, HLA-C) expressed in almost all cells and class II molecules (HLA-DR, HLA-DQ, HLA-DP) expressed mainly in cells of the immune system .
[0003] HLA class I antigens are composed of highly polymorphic α chains and almost no polymorphic β2-microglobulins, and HLA class II antigens are composed of highly polymorphic β chains and low polymorphic α chains. The α chain of class I molecules is encoded by HLA-A, HLA-B, and HLA-C ge...