Encephalic drug eluting stent

A technology for eluting stents and drugs, used in stents, medical science, surgery, etc., can solve problems such as intracranial vascular stent stenosis, and achieve the effects of dilating vascular function, inhibiting inflammatory response, and protecting blood vessels

Inactive Publication Date: 2014-07-30
ACHIEVA MEDICAL SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Aiming at how to solve the problem of intracranial vascular stent restenosis,

Method used

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  • Encephalic drug eluting stent
  • Encephalic drug eluting stent
  • Encephalic drug eluting stent

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Embodiment Construction

[0020] Below by accompanying drawing and specific embodiment content of the present invention will be further described:

[0021] Specific implementation method:

[0022] The drug-loaded layer is attached to the stent by adopting the conventional manufacturing method of the drug-eluting stent. The drug-loaded layer includes the active ingredient. The active ingredient is cilostazol. The drug-eluting stent reaches the lesion, and after the stent is expanded, the active ingredient cilostazol in the drug-loaded layer prevents restenosis in the stent. Cilostazol inhibits platelet aggregation by inhibiting phosphodiesterase 3 and increasing the concentration of cyclic adenosine monophosphate. At the same time, cilostazol has a protective effect on blood vessels, and its mechanism of action is as follows: 1) By promoting the activity of endothelial nitric oxide synthase (eNOS), the concentration of nitric oxide (NO) is increased (NO is an important vasodilation Substances that c...

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Abstract

The invention discloses an encephalic drug eluting stent in the field of medicines, and particularly relates to the drug eluting stent used for curing the encephalic atherosclerotic stenosis disease. Diseased blood vessels are expanded by the stent to improve the condition of stenosis, so as to improve the blood flow state, meanwhile, drug carried by the stent can be used for preventing a tunica elastica interna from hyperplasia, and the probability of in-stent restenosis can be lowered. The encephalic drug eluting stent comprises a conveying system, a stent body and a stent drug carrying layer, and is characterized in that one or more drug carrying layers are attached to the surface of the encephalic drug eluting stent; each drug carrying layer is composed of a polymer and an active ingredient, the active ingredient is an antiplatelet drug cilostazol, and each drug carrying layer comprises the following components by weight percent: 5 to 50 percent of the polymer and the balance of active ingredients; the active ingredients in all medicine carrying layers are the same or different. The encephalic drug eluting stent provided by the invention has the advantages that the functions of protecting blood vessels, restraining inflammation reactions, expanding blood vessels and the like can be achieved, and the purpose of preventing encephalic vascular in-stent restenosis can be achieved.

Description

technical field [0001] The invention relates to an intracranial drug-eluting stent in the field of medicine, specifically, a drug-eluting stent for treating intracranial atherosclerotic stenosis (ICS), which is expanded by the stent Diseased blood vessels can improve the stenosis, thereby improving the blood flow state. At the same time, the drugs carried by the stent can prevent excessive hyperplasia of the vascular intima and reduce the probability of in-stent restenosis. Background technique [0002] Intracranial atherosclerotic stenosis (ICS) is an important cause of ischemic stroke. Studies have shown that the 1-year stroke recurrence rate in patients with severe ICS (stenosis rate 70%-90%) is as high as 23%. The treatment of intracranial artery stent stenosis mainly includes drug therapy, interventional surgery and surgical treatment. Surgical operation has severely limited its clinical application due to its high mortality rate, high disability rate and high technic...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61L31/12A61L31/16A61F2/95
Inventor 叶萍莫述衡唐杰
Owner ACHIEVA MEDICAL SHANGHAI
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