New application of schizandrin A in preparation of product for antagonizing formaldehyde cytotoxicity

A technology of schisandrin A and formaldehyde, which is applied in the directions of antitoxins, ether/acetal active ingredients, drug combinations, etc., can solve problems such as no literature reports and the like

Active Publication Date: 2014-07-30
PEKING UNIV FIRST HOSPITAL
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] Schizandrin A mainly has pharmacological effects such as calming the nerves, protecting the liver, anti-cancer, anti-...

Method used

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  • New application of schizandrin A in preparation of product for antagonizing formaldehyde cytotoxicity
  • New application of schizandrin A in preparation of product for antagonizing formaldehyde cytotoxicity
  • New application of schizandrin A in preparation of product for antagonizing formaldehyde cytotoxicity

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, cell culture, inoculation and drug treatment:

[0023] 1. Culture SH-SY5Y cells in RPMI-1640 full medium (containing 15% inactivated fetal bovine serum by volume and 1% double antibody (the content of penicillin in 100× penicillin-streptomycin mixed solution is 8000U / ml, the content of streptomycin is 8mg / ml), put in 37℃, 5%CO 2 Incubate in an incubator and subculture every 2 days.

[0024] 2. Schizandrin A was dissolved in DMSO, and prepared into stock solution with three concentration gradients, namely 5mM, 10mM and 20mM. Formaldehyde was diluted with RPMI-1640 medium (basic medium, without double antibody and serum) to prepare a 300 mM stock solution.

[0025] 3. Experimental grouping: divided into 5 groups, namely normal control group, model group, low-concentration schisandrin A group, medium-concentration schisandrin A group, and high-concentration schisandrin A group.

[0026] (1) The treatment of each group is as follows:

[0027] SH-SY5Y cell...

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Abstract

The invention discloses a new application of schizandrin A in preparation of a product for antagonizing formaldehyde cytotoxicity. Schizandrin A can antagonize cell death and apoptosis induced by formaldehyde so as to improve the cell survival rate. The invention discloses an application of schizandrin A in preparation of a product for inhibiting the cell death rate from increasing induced by formaldehyde. Schizandrin A plays an important role in antagonizing formaldehyde cytotoxicity, and is significant for preventing diseases caused by formaldehyde.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine monomer in the preparation of a product for antagonizing formaldehyde cytotoxicity; in particular, it relates to a new application of schisandrin A in the preparation of a product for antagonizing formaldehyde cytotoxicity, which belongs to the new medicinal application of the traditional Chinese medicine monomer. Background technique [0002] The molecular formula of formaldehyde is H 2 CO, a colorless, volatile organic compound with a strong pungent odor, is one of the representative pollutants of indoor and outdoor air pollution. According to the space where formaldehyde exists, it can be divided into exogenous formaldehyde and endogenous formaldehyde. Exogenous formaldehyde mostly refers to the formaldehyde emitted into the environment by human activities, such as power generation, oil refining, automobile exhaust, paint, etc. Endogenous formaldehyde refers to the formald...

Claims

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Application Information

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IPC IPC(8): A61K31/09A61P39/02
Inventor 黎巍威王学美宋宜祥王琳琳赫荣乔郭浩
Owner PEKING UNIV FIRST HOSPITAL
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