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A kind of compound crotamiton preparation and application thereof

A compound crotamiton and crotamiton technology, applied in the field of medicine, can solve problems such as strong odor, certain irritation, contact dermatitis, etc., and achieve fast inflammation subsidence, high curative effect, and prevention of contact dermatitis. Effect

Active Publication Date: 2017-02-01
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sulfur cream, benzyl benzoate cream and other preparations are irritating due to their strong odor, and some patients may have adverse reactions such as contact dermatitis, so they cannot be accepted by patients

Method used

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  • A kind of compound crotamiton preparation and application thereof
  • A kind of compound crotamiton preparation and application thereof
  • A kind of compound crotamiton preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of compound crotamiton ointment

[0023] The composition of each 1000g ointment is as follows:

[0024]

[0025] Take glyceryl monostearate and stearic acid and heat to melt, keep the temperature at 70-80°C, take another appropriate amount of crotamiton, mometasone furoate, glycerin and water, grind them into a suspension, and slowly add to the oil phase , stir in the same direction until cooled.

Embodiment 2

[0026] Embodiment 2: the drug efficacy test of compound crotamiton ointment of the present invention

[0027] 1. Materials and methods

[0028] 1. Cases: 120 cases of scabies patients who were clearly diagnosed in the Dermatology Clinic of Shanghai Changzheng Hospital from 2010 to 2014 were selected as the research objects, and the course of the disease was 1 to 2 weeks. Inclusion criteria: history of contact infection, common group disease; papules, papules, nodules, tunnels and other rashes on the thin and tender skin; scabies can be found on the damaged parts. Exclusion criteria: pregnant and lactating women; those who are allergic to crotamiton or mometasone furoate; those who are currently using other methods to treat scabies.

[0029] 2. According to the random number table, they are equally divided into two groups. Treatment group: 60 cases, 42 males and 18 females, aged 18 to 34 years, with an average of 23.5 years. Control group: 60 cases, 41 males and 19 females, ...

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PUM

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Abstract

The invention belongs to the technical field of medicine technology and provides a compound crotamiton preparation. Active components of the preparation comprise crotamiton and mometasone furoate. The compound crotamiton preparation is suitable for treating scabies, is high in curative effect, is good in safety, has a two-week effective rate reaching 68.33% and a four-week effective rate reaching 83.33% and is free of any obvious adverse reactions.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a compound crotamiton preparation and its application in preparing medicines for treating scabies. Background technique [0002] Scabies (scabies) is commonly called as " malnutrition ", is a kind of contagious skin disease that is caused by scabies parasitism in the surface layer of human skin. Scabies belongs to the genus Acarina, also known as scabies, is a permanent parasitic mite. Parasitic in the skin of humans and mammals, invading the human body causes scabies. Scabies mites mostly parasitize on the thinner parts of the skin, such as the crevices of the fingers and their sides, the fossae of the elbows, the armpits, the folds under the breasts of women, around the navel, the groin, the penis, and the scrotum. Due to the mechanical stimulation of scabies mites digging tunnels in the cuticle of the skin and the stimulation of scabies mites secreting toxins, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61P33/14A61P17/00A61K31/167
Inventor 廖万清潘炜华陈敏方文捷
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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