Pasting film for treating oral ulcer and preparation method of pasting film

A technology for oral ulcers and film sticking, which is applied in the field of film for treating oral ulcers and its preparation, can solve problems such as short residence time, and achieve the effects of moderate dissolution rate, large drug storage amount and release area.

Inactive Publication Date: 2014-09-03
ZHANGJIAGANG SHANMU NEW MATERIAL TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: in order to overcome the short residence time of most medicine patches in the oral cavity in the prior art, it is difficult to adapt to the characteristics of the oral cavity to achieve a continuous effective drug concentration in the lesion, and to provide a film for the treatm

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A patch for treating oral ulcers, the patch is a non-woven fabric composed of nanofibers with a core-shell structure, the shell layer of the nanofibers with the core-shell structure is a polyethylene oxide shell, and the core layer of the nanofibers with the core-shell structure is dexamethasone and vitamin C The mixture of vitamin B2 and vitamin B2 has a mass ratio of 1:1:1.

[0016] A preparation method for a film for the treatment of oral ulcers, comprising the steps of:

[0017] Polyethylene oxide is formulated into an aqueous solution with a mass fraction of 4wt%, and dexamethasone, vitamin C and vitamin B2 are prepared with the above-mentioned ratio as an aqueous solution with a mass fraction of 1%, and the two aqueous solutions are respectively added to the solution supply device. The polyethylene oxide aqueous solution is used as the shell layer, and the aqueous solution of dexamethasone, vitamin C and vitamin B2 is used as the core layer, the spinning voltage i...

Embodiment 2

[0019] A patch for treating oral ulcers, the patch is a non-woven fabric composed of nanofibers with a core-shell structure, the shell layer of the nanofibers with the core-shell structure is a polyethylene oxide shell, and the core layer of the nanofibers with the core-shell structure is dexamethasone and vitamin C The mixture of vitamin B2 and vitamin B2 has a mass ratio of 1:0.5:1.

[0020] A preparation method for a film for the treatment of oral ulcers, comprising the steps of:

[0021] Polyethylene oxide is formulated into an aqueous solution with a mass fraction of 6wt%, and dexamethasone, vitamin C and vitamin B2 are formulated with the above-mentioned ratio as an aqueous solution with a mass fraction of 0.1%, and the two aqueous solutions are respectively added to the solution supply device. The polyethylene oxide aqueous solution is used as the shell layer, and the aqueous solution of dexamethasone, vitamin C and vitamin B2 is used as the core layer, the spinning vol...

Embodiment 3

[0023] A patch for treating oral ulcers, the patch is a non-woven fabric composed of nanofibers with a core-shell structure, the shell layer of the nanofibers with the core-shell structure is a polyethylene oxide shell, and the core layer of the nanofibers with the core-shell structure is dexamethasone and vitamin C The mixture of vitamin B2 and vitamin B2 has a mass ratio of 1:0.5:5.

[0024] A preparation method for a film for the treatment of oral ulcers, comprising the steps of:

[0025] Polyethylene oxide is formulated into an aqueous solution with a mass fraction of 10wt%, and dexamethasone, vitamin C and vitamin B2 are formulated with the above-mentioned ratio as an aqueous solution with a mass fraction of 0.5%, and the two aqueous solutions are respectively added to the solution supply device. The polyethylene oxide aqueous solution is used as the shell layer, and the aqueous solution of dexamethasone, vitamin C and vitamin B2 is used as the core layer, the spinning vo...

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PUM

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Abstract

The invention relates to the technical field of medical apparatuses and instruments, and particularly relates to a pasting film for treating oral ulcer and a preparation method of the pasting film. By virtue of coaxial electrostatic spinning method, dexamethasone, vitamin C and vitamin B2 are encapsulated into polyoxyethylene nano fiber in proportion. According to the pasting film for treating oral ulcer and a preparation method of the pasting film, the pasting film consists of core-shell structure nano fibers, is guaranteed to have large enough medicine storage amount and release area; moreover, the used polyoxyethylene is relatively moderate in solution rate in an oral cavity, and can continuously keep the ulcer part to have effective medicine concentration.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a film for treating oral ulcers and a preparation method thereof. Background technique [0002] Oral ulcer is a common oral mucosal disease with complex etiology and easy recurrence. In daily life, oral ulcers caused by bites, burns, abrasions, scratches, etc. are more common. Once oral ulcers are formed, it not only affects the normal life and diet of patients, but sometimes even causes systemic diseases. For oral ulcers, clinical symptomatic treatment is mainly based on topical medications. Clinical medications include powders, ointments, films, injections and other dosage forms, but most of them directly affect the curative effect due to the short action time in the mouth. Such as powders such as traditional Chinese medicine Bingboran Powder, which must be applied to the affected area during use, and the medicine will be quickly lost with saliva; ointment is difficul...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K9/70A61P1/02A61K31/525A61K31/375
Inventor 顾钰霞
Owner ZHANGJIAGANG SHANMU NEW MATERIAL TECH DEV
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