Pasting film for treating oral ulcer and preparation method of pasting film

Abstract

The invention relates to the technical field of medical apparatuses and instruments, and particularly relates to a pasting film for treating oral ulcer and a preparation method of the pasting film. By virtue of coaxial electrostatic spinning method, dexamethasone, vitamin C and vitamin B2 are encapsulated into polyoxyethylene nano fiber in proportion. According to the pasting film for treating oral ulcer and a preparation method of the pasting film, the pasting film consists of core-shell structure nano fibers, is guaranteed to have large enough medicine storage amount and release area; moreover, the used polyoxyethylene is relatively moderate in solution rate in an oral cavity, and can continuously keep the ulcer part to have effective medicine concentration.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a film for treating oral ulcers and a preparation method thereof. Background technique [0002] Oral ulcer is a common oral mucosal disease with complex etiology and easy recurrence. In daily life, oral ulcers caused by bites, burns, abrasions, scratches, etc. are more common. Once oral ulcers are formed, it not only affects the normal life and diet of patients, but sometimes even causes systemic diseases. For oral ulcers, clinical symptomatic treatment is mainly based on topical medications. Clinical medications include powders, ointments, films, injections and other dosage forms, but most of them directly affect the curative effect due to the short action time in the mouth. Such as powders such as traditional Chinese medicine Bingboran Powder, which must be applied to the affected area during use, and the medicine will be quickly lost with saliva; ointment is difficul...

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: in order to overcome the short residence time of most medicine patches in the oral cavity in the prior art, it is difficult to adapt to the characteristics of the oral cavity to achieve a continuous effective drug concentration in the lesion, and to provide a film for the treatment of oral ulcers and its preparation method, the film is composed of nanofibers with a core-shell structure to ensure its large enough drug storage capacity and release area, and the polyethylene oxide used has a relatively moderate dissolution rate in the oral cavity, which can continuously maintain the ulcer in the effective drug concentration