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A technology of use and medicine, which is applied in the field of flavin and its derivatives as a drug, can solve the problem of antidepressant effect of flavin that has not been seen yet
Active Publication Date: 2014-09-03
SICHUAN ACAD OF CHINESE MEDICINE SCI
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[0006] At present, there is no report t...
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Embodiment 1
[0038] The preparation of embodiment 1 tablet of the present invention
[0040] Preparation method: mix the flavin, starch and lactose, granulate it by conventional method, add magnesium stearate to granulate, press into tablets, make 10,000 tablets in total, and obtain a preparation containing 50 μg of flavin in each tablet.
Embodiment 2
[0041] The preparation of embodiment 2 capsules of the present invention
[0042] Raw materials: flavin 500mg, starch 2000g.
[0043] Preparation method: after uniformly mixing the flavin and starch, pack it into capsules, make 10,000 capsules in total, and obtain a preparation containing 50 μg of the flavin extract in each capsule.
Embodiment 3
[0044] The preparation of embodiment 3 tablet of the present invention
[0046] Preparation method: mix the flavin, starch and lactose, granulate it by conventional method, add magnesium stearate to granulate, press into tablets, make 10,000 tablets in total, and obtain a preparation containing 100 μg of flavin in each tablet.
[0047]Prove beneficial effect of the present invention by pharmacodynamic test below.
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Abstract
The invention provides a novel application of swertisin and a derivative thereof in preparing an antidepressant drug. The swertisin has an obvious antidepressant effect, can significantly improve functions of a monoamine neurotransmitter system, has an auxiliary therapeutic effect for depression and symptoms thereof, and provides a novel selection for treating depression clinically.
Description
technical field [0001] The present invention relates to the new application of flavin and its derivatives. Background technique [0002] Depression, belonging to mood disorders, is a syndrome characterized by significant and persistent low mood, accompanied by slow thinking, weakened will activity, and various physical symptoms. Depression is a common and frequently-occurring disease that endangers human physical and mental health, and is a major global mental problem. Its lifetime prevalence rate is 6.1%-9.5%, and about 13%-20% of people have experienced depression in their lives. Fifteen percent of people with major depressive disorder die by suicide, and suicide deaths are estimated to be as high as 1 million a year. The World Health Organization (WHO) estimates that there are about 350 million patients with depression in the world. In 1996, a survey on the "burden of disease" published by WHO showed that: based on the statistics of disability (functional impairment) cau...
Claims
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Application Information
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