Rat balance based multifunctional pain threshold measuring apparatus and method
A multi-functional, measuring instrument technology, applied in the fields of diagnostic recording/measurement, medical science, diagnosis, etc., can solve the problems of difficult to intuitively reflect the pain sensitivity, strengthen the reaction of animal heat pain, increase animal injury, etc., to avoid Influence of measurement results, simple structure, little effect of stimulus damage
Inactive Publication Date: 2014-10-15
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology
However, this method is relatively complicated, and requires prior training of experimenters and the consistency of control measurement personnel during the experiment
Repeated measurements are needed to expand the sample size of the data, and repeated measurements further increase the damage to the animal and strengthen the animal's response to heat pain
At the same time, this method is based on comparing the data of different animals, the accuracy is low, and it is difficult to intuitively reflect the pain sensitivity of a single animal at a certain point in time
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[0029] The present invention is described in further detail below in conjunction with accompanying drawing:
[0030] refer to figure 1 , figure 2 , image 3 , Figure 4 and Figure 5 The multifunctional pain threshold measuring instrument based on rat balance of the present invention includes a housing, a nail plate 3, a metal panel and a display 12, the housing includes a base 4, a box with a hollow structure, and the top of the box is provided with a top. Cover 6, the upper part of the base 4 is engaged with the lower part of the box body, the base 4 is provided with a controller 7, a temperature detection module 11, a pressure acquisition module 9, an analog-to-digital converter 8, a power supply module for providing power, and A heater 10 for heating the metal plate, a through hole 5 for fixing the rat is provided on the rear side of the box body, the input end of the controller 7 is connected with the output end of the temperature detection module 11 and the pressure...
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Abstract
The invention discloses a rat balance based multifunctional pain threshold measuring apparatus comprising a housing, a toothed plate, a metal flat plate and a display. The housing comprises a base and a box in a hollow structure. A top cover is disposed on the upper portion of the box. The upper portion of the base is connected with the lower portion of the box in a fastened manner. A controller, a heater, a temperature detection module, a pressure acquisition module, an analog-digital converter, a power module for providing power and a heater for heating the metal flat plate are disposed on the base. The rear surface of the box is provided with a through hole used for fixing a rat. The input end of the controller is connected with both the output end of the temperature detection module and the output end of the pressure acquisition module. The output end of the controller is connected with both the control end of the heater and the input end of the display. The toothed plate or the metal flat plate is disposed on the pressure acquisition module when pain threshold of the rat is measured. The invention further discloses a rat balance based multifunctional pain threshold measuring method. The rat balance based multifunctional pain threshold measuring apparatus and method allows measurement of the pain threshold information of rats.
Description
technical field [0001] The invention belongs to the technical field of medical experimental animal devices, and relates to a rat balance-based multifunctional pain threshold measuring instrument and a measuring method thereof. Background technique [0002] Pain sensitization includes mechanical pain, thermal radiation pain, inflammatory pain, spontaneous pain and other types of pain. The principle of pain threshold measurement is to stimulate the soles of the hind legs of animals noxiously, judge the pain threshold according to the animal's behavioral response, and determine the degree of pain sensitivity through the difference between the experimental group and the control group. Measurements of mechanical pain and thermal pain have become the most commonly used behavioral measures of pain models. [0003] There are many traditional pain threshold measurement tools, such as mechanical pain measurement using Von Frey or tenderness quantitative measuring instrument, radiant ...
Claims
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Inventor 方科赵湘辉徐浩吴江武桂铃任培鹏杨蓬勃
Owner FOURTH MILITARY MEDICAL UNIVERSITY