A traditional Chinese medicine composition for treating cardiac autonomic neuropathy

A technology of autonomic neuropathy and composition, which is applied in drug combinations, nervous system diseases, cardiovascular system diseases, etc., and can solve the problems of heart rate variability decrease in heart disease patients

Active Publication Date: 2017-04-05
THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Purpose of the present invention: aiming at the deficiencies of the prior art, mainly solving the problem of heart rate variability decrease in clinical heart disease patients, providing a traditional Chinese medicine composition capable of maintaining or regulating cardiac sympathetic-vagal balance and treating cardiac autonomic neuropathy

Method used

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  • A traditional Chinese medicine composition for treating cardiac autonomic neuropathy
  • A traditional Chinese medicine composition for treating cardiac autonomic neuropathy
  • A traditional Chinese medicine composition for treating cardiac autonomic neuropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Examples 1 to 3 are derived from animal experiments. Example 1 is used to verify the preventive and therapeutic effect of the Chinese medicine composition of the present invention on cardiac autonomic remodeling in diabetic rats. Therapeutic effect of mouse autonomic nerve injury, embodiment 3 is used for verifying the preventive effect of different osmanthus peony root compatibility of Chinese medicine composition of the present invention on diabetic cardiac autonomic neuropathy; Embodiment 4 and embodiment 5 are selected from clinical trial research, can further illustrate this invention Invention of traditional Chinese medicine composition for the treatment and prevention of cardiac autonomic neuropathy.

[0048] animal research

[0049] Example 1

[0050] Objective: To observe the changes in the cardiac microenvironment during the remodeling process of the diabetic cardiac autonomic nerves, and to explore the preventive and therapeutic effects of the traditional Ch...

Embodiment 2

[0105] Objective: To observe the cardiac autonomic nerve injury in diabetic rats and the therapeutic effect of the traditional Chinese medicine composition of the present invention on it.

[0106] formula:

[0107] The main drug ratio of Astragalus: Guizhi: Radix Paeoniae Alba: Radix Glycyrrhiza is 10:3:3:2, and the ratio of auxiliary drugs is adjustable within the scope of the weight ratio of the present invention; take the raw medicinal materials, add 10 times the amount of water to reflux and extract twice, and the second 1.5 hours for the first time, 1 hour for the second time, combine the extracts, filter, concentrate under reduced pressure to a relative density of 1.20-1.25 (70-80°C), add sugar powder and dextrin granules, dry below 60°C, and prepare Get granules, 2g crude drug / 1g granules. Prepare an aqueous solution when in use, and the concentration is 1g crude drug / ml solution.

[0108] Chinese medicine composition of the present invention and Mecobalm carry out an...

Embodiment 3

[0149] Objective: To observe the preventive effect of the traditional Chinese medicine composition of the present invention and the compatibility of different ratios of osmanthus peony root on diabetic autonomic neuropathy.

[0150] Prescription: The ratio of main ingredients astragalus: cassia twig: white peony: licorice 6g is 10:3:3:2, 10:6:3:2, 10:3:6:2 respectively, and the ratio of auxiliary drugs is in the weight ratio of the present invention It can be adjusted within the range; the raw medicinal materials are taken according to the proportion, and boiled in water to a final concentration of 1.5g (crude drug) / ml (processed and produced by the preparation room of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine).

[0151] Chinese medicine composition of the present invention and Mecobalm carry out animal test simultaneously, prove its medicinal effect, and its method and result are as follows:

[0152] 1. Experimental materials

[0153] (1) E...

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Abstract

The invention provides a traditional Chinese medicinal composition for treating cardiovascular autonomic neuropathy, belonging to the field of traditional Chinese medicines. The composition is prepared from main drugs and auxiliary drugs, wherein the main drugs comprise the following components by weight: 15-45g of astragalus membranaceus, 9-27g of cassia twig, 9-27g of radix paeoniae alba and 6g of licorice root; and the auxiliary drugs comprise the following components by weight: 18-20g of radix ophiopogonis, 18g of kudzu vine root, 20g of rhizoma anemarrhenae and 3g of notoginseng powder. Based on the components, the composition further comprises arbitrary one or combination of the following raw materials by weight: 6-9g of coptis chinensis, 18g of ligusticum wallichii, 12-20g of angelica sinensis, 12g of codonopsis pilosula, 20g of rhizoma atractylodis macrocephalae, 9g of schisandra chinensis and 12g of cornus officinalis. The traditional Chinese medicinal composition is capable of protecting cardiac nerves and repairing injured nerves so as to maintain the balance of cardiac sympathetic-pneumogastric nerves, improve heart rate variability and protect functions of cardiac nerves, has a remarkable curative effect, is easily accepted by patients, and has the advantages of few raw material components, low cost and simple usage.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine composition for treating cardiac autonomic neuropathy. Background technique [0002] Cardiac autonomic neuropathy is the damage of cardiac nerves caused by various heart diseases such as hypertension, coronary heart disease, heart failure, arrhythmia, myocarditis and systemic diseases such as diabetes, and the destruction of cardiac sympathetic-vagal balance. The disease seriously affects the progress and prognosis of heart disease, and affects the mortality of patients. Heart rate variability (heart rate variability, HRV) refers to the small changes in sinus rhythm within a certain period of time, which reflects the balance and regulation of the autonomic nervous system. HRV is a non-invasive method for detecting cardiac autonomic function. It can quantitatively analyze the tension of cardiac sympathetic nerve and vagus nerve. The decrease...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61P9/00A61P25/00
Inventor 李晓姜萍杨金龙
Owner THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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