Whole blood perfusion bioartificial liver system

Abstract

A hemoperfusion bio-artificial liver system comprises a blood circulation portion, a bioreactor circulation portion and a cell renewing system portion; the three portions are communicated through a pipeline. The bioreactor circulation portion comprises a bio-artificial liver reactor unit composed of one or a plurality of bio-artificial liver reactors; outer space of the bio-artificial liver reactors is filled with L-02 cells to allow better therapeutic effect and safety. The cell renewing system portion is used for renewing the L-02 cells. The hemoperfusion bio-artificial liver system has the advantages that the therapeutic cells in the reactors can be renewed timely in the therapy process, continuous and stable therapeutic effect is guaranteed, interrupting the therapy to replace the reactors is not required, the therapeutic time is shortened, the whole system can be manually operated or full-automatically controlled via a PLC (programmable logic controller), the frequent sampling and detection is omitted for medical staff, real-time monitoring is achieved, and the system is efficient, safe, well practical and applicable to industrial production.

Description

technical field [0001] The invention relates to the technical field of bioartificial liver, in particular to a whole blood perfusion bioartificial liver system. Background technique [0002] my country is the country with the most serious liver disease in the world, with more than 1 million new cases of liver failure each year, and about 500,000 liver failure patients die each year due to lack of effective treatment. There is only one chance of cure, that is, liver transplantation, but due to the difficulty in obtaining livers, the long waiting time, or no chance to get a donor liver at all, most patients have no chance of survival at all. Therefore, an artificial liver system is urgently needed to maintain the patient's life, waiting for the opportunity of liver transplantation, or the opportunity of the patient's own liver recovery. [0003] However, due to the high cost of the traditional artificial liver (that is, the physical artificial liver), most patients cannot aff...

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Problems solved by technology

[0005] The purpose of the present invention includes two aspects. On the one hand, it is to overcome the defects of high cost, pollution and safety risks in the structure of the existing bioartificial liver system, and to provide a safe and reliable whole blood perfusion bioartificial liver system to realize uninterrupted treatment; on the other hand, it is used with the bioartificial liver reactor filled with L-02 cells to overcome the defects of low curative effect and poor safety of existing cell sources. L-02 cells have the advantages of good liver function, strong value-added ability and safety , used in the whole blood perfusion bioartificial liver system of the present invention, to achieve a thorough improvement in cells and structure, better curative effect, make the damaged liver more likely to regenerate, or provide more effective support for patients with liver failure, Until a donor organ for transplant can be found

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