bioartificial liver system

Abstract

A bioartificial liver system, including three parts: plasma separation / blood reinfusion cycle, bioreactor cycle, and cell renewal system, the three parts are connected through pipelines, and the bioreactor cycle consists of one or more bioartificial liver reactors The bioartificial liver reactor group, the outer space of the bioartificial liver reactor is filled with L-02 cells, so that the therapeutic effect and safety are better; the cell renewal system is used to renew the L-02 cells, and the present invention can be used in the treatment process The treatment cells in the reactor can be updated in time to ensure continuous and stable curative effect, and there is no need to interrupt the treatment for the replacement of the bioartificial liver reactor, which shortens the treatment time. The whole system can be fully automated by manual operation or PLC, eliminating the need for The frequent sampling and testing work of medical staff realizes real-time monitoring, which is efficient and safe, has good practicability, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of bioartificial liver, in particular to a bioartificial liver system. Background technique [0002] my country is the country with the most serious liver disease in the world, with more than 1 million new cases of liver failure each year, and about 500,000 liver failure patients die each year due to lack of effective treatment. There is only one chance of cure, that is, liver transplantation, but due to the difficulty in obtaining livers, the long waiting time, or no chance to get a donor liver at all, most patients have no chance of survival at all. Therefore, an artificial liver system is urgently needed to maintain the patient's life, waiting for the opportunity of liver transplantation, or the opportunity of the patient's own liver recovery. [0003] However, due to the high cost of the traditional artificial liver (that is, the physical artificial liver), most patients cannot afford it, the curative e...

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Problems solved by technology

[0005] The purpose of the present invention includes two aspects. On the one hand, it is to overcome the defects of high cost, pollution and safety risks in the structure of the existing bioartificial liver system, and to provide a safe and reliable bioartificial liver system to realize uninterrupted treatment; On the one hand, it is used in conjunction with the bioartificial liver reactor filled with L-02 cells to overcome the defects of low efficacy and poor safety of existing cell sources. L-02 cells have the advantages of good liver function, strong value-added ability, and safety. The bioartificial liver system of the present invention achieves a thorough improvement in cells and structure, better curative effect, more chances for damaged liver to regenerate, or provide more effective support for patients with liver failure until a transplantable liver can be found donor organ

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