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Gastrointestinal contrast agent and preparation method thereof

A technology for gastrointestinal imaging and traditional Chinese medicine, which is applied in the preparation of X-ray contrast agents, pharmaceutical formulations, and medical preparations containing active ingredients, etc. High safety and comfort, remarkable acid suppression effect, stable physical and chemical properties

Inactive Publication Date: 2014-12-10
李晓光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has clinical problems such as poor taste, unsatisfactory gastrointestinal filling, long preparation time, and easy to cause cross-infection. The injected contrast agent can affect various systems of the body, and various symptoms appear in different degrees. The main manifestations of mild reactions are: In patients with reactions such as skin flushing, itching, urticaria, dizziness, headache, burning sensation, eyelid edema, increased eye and nasal secretions, nausea, vomiting, chills, fever, local pain, and dyspnea, the degree of reaction is related to the contrast medium used In addition, its function is single, not only has no diagnostic and therapeutic effect on gastrointestinal ulcers, stones and other diseases, but also inevitably adds an extra burden to the gastrointestinal tract, increasing the pain of the patient, and causing great harm to the medical staff. people caused great trouble
And sometimes it will cause pain or discomfort in patients, so it cannot be applied to patients with gastric bleeding

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0025] The invention also provides a preparation method of a gastrointestinal contrast agent, which is characterized in that it is prepared by mixing and mixing 60-80 parts by weight of barium sulfate and 10-20 parts by weight of a traditional Chinese medicine extract.

[0026] According to the traditional Chinese medicine composition and preparation principles, the present invention carefully develops the traditional Chinese medicine composition, and provides a kind of Chinese medicine extract that has the advantages of strong pertinence, good curative effect, short cycle, low price, and no toxic and side effects, and can be accepted by patients. gastrointestinal contrast agent.

Embodiment 1

[0029] Take honeysuckle 10g, astragalus 10g, licorice 15g, Atractylodes macrocephala 20g, poria cocos 20g, angelica 10g, yam 20g, medlar 20g, plantain 10g, hawthorn 20g, codonopsis 10g, jujube 15g, Chuanqiong 10g, rehmannia glutinosa 10g, tangerine peel 10g, Ligustrum lucidum 10g, chopped and put into 6 times the amount of water, heated and refluxed twice, 40 minutes each time, to extract the active ingredient, combined the 2 extracts and let stand; put the dregs extracted with water into 6 times the amount in ethanol, heated and refluxed for 2 extractions, each time for 35 minutes, the 2 extracts were combined and left standing; the above two extracts were combined, the ethanol was recovered under reduced pressure and concentrated until the concentration of the medicinal solution was 0.6g crude drug / mL. After filtration, the relative density of the filtrate is about 1.18 at 20°C; reduce the pressure to 0.04MPa, keep the temperature at 60°C, concentrate to a relative density of...

Embodiment 2

[0031]Take 30g honeysuckle, 20g astragalus, 30g licorice, 30g Atractylodes macrocephala, 30g poria cocos, 20g angelica, 30g yam, 30g wolfberry, 20g plantain, 30g hawthorn, 20g codonopsis, 30g jujube, 20g Chuanqiong, 20g rehmannia glutinosa, 25g tangerine peel, Ligustrum lucidum 20g, chopped and put into 6 times the amount of water, heated and refluxed for 2 extractions, 1 hour each time, to extract the active ingredients, combined the 2 extracts and left standing; put the dregs extracted with water into 6 times the amount of water in ethanol, heated and refluxed twice for 55 minutes each time, and the two extracts were combined and left standing; the above two extracts were combined, and the ethanol was recovered under reduced pressure and concentrated until the concentration of the medicinal solution was 0.6g crude drug / mL. After filtration, the relative density of the filtrate is about 1.18 at 20°C; depressurize to 0.07MPa, keep the temperature at 80°C, concentrate to a relat...

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Abstract

The invention discloses a gastrointestinal contrast agent which is prepared by uniformly mixing 60-80 weight parts of barium sulfate and 10-20 weight parts of traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is prepared from the following raw material components: honeysuckle, astragalus, liquorice, bighead atractylodes rhizome, Poria cocos, Angelica sinensis, Chinese yam, medlar, plantain herb, hawthorn, Codonopsis pilosula, Chinese-date, Ligusticum wallichii, Rehmannia Glutinosa, dried tangerine or orange peel and glossy privet fruit. The contrast agent is clear in image, obvious in contrast and stable in physical and chemical properties, has the treatment effects of eliminating dampness and heat, regulating the flow of vital energy and soothing middle-Jiao and warming the middle-Jiao and invigorating the circulation of blood, can provide a protective effect for the gastrointestinal tract, relieves the symptoms such as stomachache, gastric acid, hematemesis and emesis of patients, is obvious in acid inhibition effect, does not have any adverse reaction, has high safety and comfort level and is suitable for clinical gastrointestinal conventional and special examination and ultrasound contrast.

Description

technical field [0001] The invention relates to the field of contrast agents, in particular, the invention relates to a gastrointestinal contrast agent containing traditional Chinese medicine extracts, and the invention also relates to a preparation method of the gastrointestinal contrast agent. Background technique [0002] Contrast agent (also known as contrast agent, contrast media) is one of the most commonly used drugs in interventional radiology operations. It is a chemical product that is injected (or taken) into human tissues or organs to enhance the effect of observation, and is mainly used for blood vessels. , Display of the body cavity. The density of these products is higher or lower than that of the surrounding tissue, and the resulting contrast is used to display images with certain devices. After using contrast agents, the diagnostic images are clearer, thus helping doctors to make more reliable diagnoses. [0003] In gastroenterology clinical practice, gastr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/04A61K36/8945A61P1/00
Inventor 李晓光
Owner 李晓光
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