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A kind of preparation method of composite hydrogel

A composite hydrogel and aqueous solution technology, applied in medical science, prosthesis, etc., can solve the problems of not being able to simulate all the properties of natural bone, the mechanical properties of CS scaffolds being easy to bend, and not having osteoinductivity, so as to overcome the lack of mechanical properties. The effect of improved mechanical properties and increased compressive stiffness

Active Publication Date: 2015-08-12
WUTONG (NANJING) TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CS scaffolds bend easily and are not mechanically as good as natural bone, so cannot load-support implants
The composite of ceramic material and CS scaffold can improve its mechanical properties, but CS itself is not osteoinductive, so CS scaffold itself cannot simulate all the properties of natural bone

Method used

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  • A kind of preparation method of composite hydrogel
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Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1: Preparation method of hydroxyapatite / chitosan / polyacrylamide composite hydrogel

[0024] (1) Preparation of hydroxyapatite (HA) aqueous solution: Dissolve 0.1g hydroxyapatite (HA) powder of 12μm in 5mL secondary water, shake and stir to fully dissolve, and obtain 0.02g / mL hydroxyapatite (HA) powder Milky white HA solution;

[0025] (2) Preparation of chitosan (CS) aqueous solution: Dissolve 0.05g of chitosan (CS) powder in 5mL of secondary water, then add 0.2mL of acetic acid, and finally oscillate and stir to dissolve fully and quickly, that is, the concentration is 0.01 g / mL milky yellow CS solution;

[0026] (3) Preparation of cross-linking agent (MBA) aqueous solution: Dissolve 0.02g of cross-linking agent N,N'-methylenebisacrylamide (MBA) in 5mL of secondary water, and ultrasonically oscillate for 2 minutes to disperse the solution evenly to obtain the concentration 0.004g / mL crosslinking agent aqueous solution;

[0027] (4) Preparation of initiator...

Embodiment 2

[0039] Example 2: Preparation method of hydroxyapatite / chitosan / polyacrylamide composite hydrogel

[0040] (1) Preparation of hydroxyapatite (HA) aqueous solution: Dissolve 0.2g of 12μm hydroxyapatite (HA) powder in 10mL of secondary water, and oscillate and stir to fully dissolve, that is, the concentration of 0.02g / mL Milky white HA solution;

[0041] (2) Preparation of chitosan (CS) aqueous solution: Dissolve 0.1g of chitosan (CS) powder in 10mL of secondary water, then add 0.2mL of acetic acid, and finally oscillate and stir to dissolve fully and quickly, that is, the concentration is 0.01 g / mL milky yellow CS solution;

[0042] (3) Preparation of crosslinking agent aqueous solution (MBA): Dissolve 0.04g of crosslinking agent N,N'-methylenebisacrylamide (MBA) in 10mL of secondary water, and ultrasonically oscillate for 2 minutes to disperse the solution evenly, and obtain the concentration 0.004g / mL crosslinking agent aqueous solution;

[0043] (4) Preparation of init...

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Abstract

The invention discloses a preparation method for composite hydrogel and belongs to the technical field of polymers. The preparation method comprises the following steps: firstly, preparing hydroxyapatite (HA) and chitosan (CS) into solution; secondly, doping the solution in a polyacrylamide (PAM) network structure. According to the preparation method, the preparation process is simple and convenient to operate and the cost is reduced; besides, the obtained material overcomes the defects that a CS stent is easily bent and is poor in mechanical property, and retains good mechanical properties of tensile strength and compression resistance endowed by the HA; in the preparation process, the HA and the CS which have good biocompatibility are doped in the PAM network structure, and good mechanical properties are endowed for a hydrogel material. Therefore, the composite material can be used as a replacement material of cartilage and has potential application value in the tissue engineering.

Description

technical field [0001] The invention relates to a preparation method of a composite hydrogel, which belongs to the field of polymer materials. Background technique [0002] Due to its good biocompatibility, polyacrylamide (PAM) hydrogel has aroused widespread interest in the biological application community, and the biological application community uses it in the fields of tissue engineering scaffold materials, cartilage tissue replacement materials, drug carriers, etc. ( J. P. Gong, Advanced MateriaLs , 2003, 15, 1155-1158). In particular, hydrogel scaffolds with certain strength have been applied to the research and development of products such as bone, cartilage and muscle. The strength of the hydrogel has a certain relationship with the degree of cross-linking of the gel and its use conditions. However, the general hydrogel lacks an effective energy dissipation mechanism due to the widely distributed long chains forming random cross-linking points through traditional c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/12A61L27/20A61L27/16
Inventor 武晓刚王艳芹岑海鹏于维伦郭媛张永刚陈维毅
Owner WUTONG (NANJING) TECH CO LTD
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