A mass spectrometer for online reaction and detection of ions and molecules in vacuum
A technology of ion molecules and vacuum, which is applied in the field of mass spectrometers and mass spectrometry devices, can solve the problems of free radical reactions, unstable intermediates, etc.
Inactive Publication Date: 2016-06-08
INST OF CHEM CHINESE ACAD OF SCI
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Problems solved by technology
Some methods for on-line detection of chemical reactions, such as nano-ESI double-spray method and DESI, etc., are mostly carried out under normal pressure conditions, and some intermediates are disturbed by various factors such as solvents and air and cannot exist stably, especially in The free radicals generated under electrification may have a certain impact on the reaction
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[0027] The experimental methods used in the following examples are conventional methods unless otherwise specified.
[0028] The present invention will be further described below in conjunction with the accompanying drawings, but the present invention is not limited to the following embodiments.
[0029] like figure 1 As shown, it is a structural schematic diagram of a mass spectrometer for online reaction and detection of ions and molecules in a vacuum according to the present invention, which includes a mass spectrometer and a tee pipe 1 matched therewith. The injection port 4 of the mass spectrometer is connected to the tee pipe 1 (the interface is provided with 1 / 4-28UNF external thread) through threads; the injection tube I2 and the injection tube II3 are connected to the tee pipe through a ferrule nut (not shown in the figure) 1 connected; the ion transfer tube is replaced by the part of the injection tube I2 inserted into the tee tube 1, and the sample molecular ions e...
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The invention discloses a mass spectrometry device for online vacuum reaction and detection of ions and molecules. The mass spectrometer includes a mass spectrometer and a multi-way tube matched with it; an outlet of the multi-way tube is connected with a sample inlet of the mass spectrometer, and other outlets are respectively connected with a sample inlet tube. The present invention has the following advantages: (1) a multi-way tube is connected between the mass spectrometer sample inlet and the sample tube to realize multi-component sample injection, and each reaction raw material can also be mixed in advance in the three-way tube, and the sample enters the vacuum The cavity reaction eliminates the interference of the environment under normal pressure and solves the air-sensitive reaction, which is beneficial to the detection of the intermediate process of the reaction, and can also detect some transient unstable intermediates. (2) The present invention can not only be used for the detection of on-line reaction, also can be used for conventional analysis, can realize the on-line monitoring to ion-molecular reaction, ion-ion reaction and molecular intermolecular reaction under (sub)vacuum environment, for vacuum gas-phase reaction and ultra-vacuum The study of the fast reaction mechanism is of great significance.
Description
technical field [0001] The invention relates to a mass spectrometry device used for online vacuum reaction and detection of ions and molecules, and belongs to the related field of mass spectrometers. Background technique [0002] The study of reaction mechanism is of great significance in chemical synthesis. Not only because the reaction mechanism can be used as a guide to find ways to improve the reaction yield and selectivity, but also to use the reaction mechanism to find the reaction law, predict various side reactions that may occur, and even design new reactions. Therefore, the exploration and research of the reaction mechanism has been It is one of the hot spots in organic chemistry. At present, there are many methods for studying the reaction mechanism, such as spectroscopy, NMR, and computational simulation. However, most methods are indirect monitoring, and cannot directly give the molecular composition of reaction intermediates, and no method can detect all reac...
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IPC IPC(8): G01N30/72
Inventor 聂宗秀谢小波何清侯剑陈素明熊彩侨刘会会
Owner INST OF CHEM CHINESE ACAD OF SCI