Multifunctional targeting vinorebine lipidosome and preparation method thereof

An isovinblastine and multifunctional technology, which is applied in the field of multifunctional targeted isovinblastine liposome and its preparation, can solve problems such as undiscovered, and achieve the effects of improving effect, reducing toxic and side effects, and increasing distribution.

Active Publication Date: 2014-12-24
大连博格林生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, PEI has been widely studied as a non-viral gene carrier, but no modification of polyethyleneimine and choles...

Method used

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  • Multifunctional targeting vinorebine lipidosome and preparation method thereof
  • Multifunctional targeting vinorebine lipidosome and preparation method thereof
  • Multifunctional targeting vinorebine lipidosome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0052] 1. Instruments and reagents.

[0053] 1.1. Instruments: electronic analytical balance (AY220, Shimadzu Corporation of Japan); electric heating constant temperature water bath (HH-4, Shanghai No. 5 Medical Device Factory); rotary evaporator (RE-52AA, Shanghai Yarong Biochemical Instrument Factory); ultrasonic cell Crushing machine (JY92-2D, Ningbo Xinzhi Biotechnology Co., Ltd.); liposome extruder (LF-1, Canada AVESTIN company); polycarbonate membrane (pore size 400nm, 200nm, 100nm, Germany Whatman company) ; constant temperature oscillator (SHZ-82, Shanghai Yichun Industrial Co., Ltd.); matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS, Japan Shimadzu Corporation); laser scattering particle size analyzer (Zetasizer 3000HS, UK Marl Wen Company); Transmission Electron Microscope (Tecnai G220ST, FEI Company of the United States); Atomic Force Scanning Probe Microscope (SPI3800N, Japan Seiko Co., Ltd.); Scanning Electron Microscope (...

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Abstract

The invention discloses a multifunctional targeting vinorebine lipidosome which is composed of vinorebine, lipid materials and functional targeting ligand; the lipidosome is a bi-molecule structure in which a water-solubility cavity is arranged; vinorebine is encapsulated in the water-solubility cavity; the lipid materials are composed of lecithin, cholesterol, polyethylene glycol-DSPE; the functional targeting ligand is composed of modifications on the lipidosome surface and targeting materials in the bi-molecule layer of the lipidosome; the mentioned targeting materials are tetrandrine encapsulated in the bi-molecule layer of the lipidosome; the mentioned modifications are vapreotide-polyethylene glycol 1000 vitamin E succinate and cholesterol-polyethylene glycol-polyethyleneimine. The invention further discloses a preparation method of the multifunctional targeting vinorebine lipidosome, through the method, drugs can be targeted into brain glioma positions after being crossed over blood brain barriers, thereby increasing drug distribution in brain tumor positions and improving chemotherapeutic efficacy.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a multifunctional targeted vinblastine liposome for treating glioma and a preparation method thereof. Background technique [0002] As one of malignant tumors, glioma has become one of the top ten causes of cancer death, seriously threatening people's lives and health. At present, glioma mainly adopts surgical treatment, radiotherapy and chemical drug treatment in clinic. Gliomas are characterized by strong infiltration and can quickly infiltrate and destroy normal brain tissue structures. Therefore, it is impossible to completely cure gliomas by surgical resection in clinical practice. Radiation therapy cannot completely remove glioma cells due to the limitation of its own treatment accuracy, and this method has large side effects and obvious damage to normal cells. The main reason for the failure of chemotherapy is that it is difficult for chemotherapy dru...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/475A61K47/42A61K47/34A61K47/22A61P35/00
Inventor 李学涛程岚姜英吕佳袁子民刘玉强赵琳
Owner 大连博格林生物科技有限公司
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