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Application of composition in preparation of medicine for treating liver insulin resistance

A technology of insulin resistance and composition, which is applied in the direction of drug combination, digestive system, metabolic diseases, etc., and can solve problems such as high price and unsatisfactory efficiency

Inactive Publication Date: 2015-01-14
WUXI XINDA MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, in the prior art, the therapeutic agent for hepatic insulin resistance is often expensive, and the efficiency is often not satisfactory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Application of a composition in the preparation of a drug for treating liver insulin resistance, the composition comprising a therapeutically effective amount of 1'-(1H-indazole-5-carbonyl)-1-isopropyl-4,6-di Hydrogenspiro[indazole-5,4'-piperidin]-7(1H)-one, and a therapeutically effective amount of 4-[5-cyano-4-({2-fluoro-4-[1-(2 -Hydroxyethyl)-1H-tetrazol-5-yl]phenoxy}methyl)-1H-pyrazol-1-yl]piperidine-1-carboxylic acid isopropyl ester, the mass ratio of the two is 1: 1.

[0022] Experiments have proved that the combined use of the two drugs can effectively treat hepatic insulin resistance, and while treating hepatic insulin resistance, it can also treat accompanying symptoms such as hypertension and diabetes.

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PUM

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Abstract

The invention discloses application of a composition in preparation of a medicine for treating liver insulin resistance. The composition contains a therapeutically-effective amount of 1'-(1H-indazol-5-carbonyl)-1-isopropyl-4,6-dihydrospiro[indazol-5,4'-piperidine]-7(1H)-one and a therapeutically-effective amount of 4-[5-cyano-4-({2-fluoro-4-[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]phenoxy}methyl)-1H-pyrazol-1-yl]piperidin-1-isopropyl formate which have the mass ratio of (3: 1) to (1: 3). Proved by experiments, by using the two kinds of drugs in a combined manner, the liver insulin resistance can be effectively treated, and concomitant symptoms, such as hypertension and diabetes, can be treated while the liver insulin resistance is treated.

Description

technical field [0001] The invention relates to a medicament, in particular to the application of a composition in the preparation of a medicament for treating liver insulin resistance. Background technique [0002] Insulin resistance (English: Insulin resistance) refers to a condition in which normal amounts of insulin are insufficient to produce a normal insulin response to fat cells, muscle cells, and liver cells. In adipocytes, insulin resistance leads to hydrolysis of stored triglycerides, which increases plasma free fatty acid levels. In muscle cells, insulin resistance reduces glucose uptake; in hepatocytes, it reduces glucose stores, both leading to elevated blood glucose levels. High insulin and high glucose levels in plasma caused by insulin resistance often lead to metabolic syndrome, gout, and type 2 diabetes. [0003] In a person with a normal metabolism, insulin is secreted by the β-cells in the pancreas after eating, which sends a signal to the insulin-sensi...

Claims

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Application Information

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IPC IPC(8): A61K31/454A61P3/10A61P9/12A61P1/16A61P5/50A61K31/438
CPCA61K31/454A61K31/438
Inventor 王岳荣
Owner WUXI XINDA MEDICAL DEVICE