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Compound cefquinome sulphate injection

A technology of cefquinoxime sulfate and injection, which is applied in the field of compound preparations of beta-lactam antibiotics, can solve the problems of complex antigenic determinants, inaccurate immune effects, differences in immune mechanisms, etc., and achieves good therapeutic effect and high antibacterial activity. , the effect of reducing the dosage

Active Publication Date: 2015-02-18
CHONGQING TAITONG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, vaccine immunization, due to the complexity of intestinal microbial antigens and epitopes, the immune mechanism is slightly different, and the immune effect is not exact
With the clinical abuse of antibacterial drugs, the resistance of bacteria such as Escherichia coli is very common, such as gentamicin, oxytetracycline, norfloxacin and other drugs commonly used in clinical efficacy are reduced

Method used

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  • Compound cefquinome sulphate injection
  • Compound cefquinome sulphate injection
  • Compound cefquinome sulphate injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012]

[0013] Add cefquinome sulfate and sodium sulfite to 300ml of water for injection in turn; dissolve hydroxypropyl-β-cyclodextrin in 400ml of water for injection, and slowly add matrine under stirring until completely dissolved; combine the two solutions and adjust the pH To 5-6, add water for injection to 1000ml, add activated carbon to stir, filter, sterilize, and fill.

Embodiment 2

[0015]

[0016] Add cefquinome sulfate and sodium sulfite to 300ml of water for injection in turn; dissolve hydroxypropyl-β-cyclodextrin in 400ml of water for injection, and slowly add matrine under stirring until completely dissolved; combine the two solutions and adjust the pH To 5-6, add water for injection to 1000ml, add activated carbon to stir, filter, sterilize, and fill.

Embodiment 3

[0018]

[0019] Add cefquinome sulfate and sodium sulfite to 300ml of water for injection in turn; dissolve hydroxypropyl-β-cyclodextrin in 400ml of water for injection, and slowly add matrine under stirring until completely dissolved; combine the two solutions and adjust the pH To 5-6, add water for injection to 1000ml, add activated carbon to stir, filter, sterilize, and fill.

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Abstract

The invention provides a compound cefquinome sulphate injection which has a synergetic antibacterial effect. The compound cefquinome sulphate injection disclosed by the invention comprises the following components in parts by weight: 1-4 parts of cefquinome sulphate, 1-2 parts of sophocarpidine, 0.5-1 part of sodium sulfite and 1-2 parts of hydroxypropyl-beta-cyclodextrin. The compound cefquinome sulphate injection disclosed by the invention is high in stability, simple in preparation process and accurate in curative effect on colibacillosis in pig, and has a good inhibiting effect on colibacillosis in pig; the dosage of a prescribed preparation can be reduced; the treatment cycle can be shortened; and thus, the compound cefquinome sulphate injection disclosed by the invention has wide market prospect.

Description

technical field [0001] The invention relates to a compound preparation of β-lactam antibiotics, in particular to an injection of cefquinome sulfate and matrine. Background technique [0002] Porcine colibacillosis is a group of intestinal infectious diseases of piglets caused by pathogenic Escherichia coli. There are three common types of piglet diarrhea, piglet pullorum and piglet edema, which are characterized by enteritis and enterotoxemia. Swine dysentery, also known as early-onset colibacillosis, is an acute and fatal infectious disease of newborn piglets caused by a certain serotype of Escherichia coli. It mainly occurs in piglets within a few hours after birth to within 5 days of age, and is most common at 1-3 days of age. Pullorum is also known as delayed colibacillosis. It mainly infects piglets aged 10-30 days. It has happened in many pig farms in our country. Swine edema disease is an acute fatal disease caused by the toxin produced by the massive reproductio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K9/08A61P31/04
CPCA61K9/08A61K31/546
Inventor 李良洪
Owner CHONGQING TAITONG ANIMAL PHARMA
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