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A preparation method of medicinal extract containing caragana seeds

A technology of caragana seeds and extracts, which is applied in the field of preparation of medicinal extracts containing Caragana seeds, can solve the problems of destroying active ingredients of plants, unquantifiable process parameters, and low relative concentration of medicinal active ingredients, and achieves technological parameters. Quantifiable, process controllable, process more effective

Active Publication Date: 2018-05-08
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to provide a preparation method of medicinal extract containing Caragana seed, aiming to solve the traditional preparation method of boiling oil or burning charcoal to grind into powder when using Caragana seed to treat dermatitis, psoriasis, yellow water sore and impetigo sore There are problems that the process parameters cannot be quantified, the active ingredients of the plant are destroyed, and the relative concentration of the prepared medicinal active ingredients is low

Method used

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  • A preparation method of medicinal extract containing caragana seeds
  • A preparation method of medicinal extract containing caragana seeds

Examples

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preparation example Construction

[0044] Such as figure 1 As shown, the preparation method of the medicinal extract containing caragana seeds according to the embodiment of the present invention includes the following steps:

[0045] S101: Extraction and enrichment: open the first valve, the second valve, the third valve, and the fourth valve, dry and crush the caragana seeds and put them into the extraction kettle. Set the pressure of the extraction kettle to 25~35MPa and the temperature to 40℃~50℃,CO 2 The flow rate is 25-40L / h, under these conditions, the caragana seeds are extracted and enriched for 60-110min;

[0046] S102: Pressure reduction separation: Set the gradient temperature and pressure reduction program in the first separation kettle, that is, reduce the pressure by 0.208MPa per minute and 0.083°C per minute within 120 minutes, until the pressure drops to 0-10MPa and the temperature drops to 30~ Maintain at 35°C for 15-30 minutes to obtain the medicinal extract of Caragana korshinskii seed;

[0047] ...

Embodiment

[0057] Example: A preparation method of a medicinal extract containing Kagan seeds includes the following steps:

[0058] Step one, extraction and enrichment: open the first valve, the second valve, the third valve, and the fourth valve, and load the dried and crushed 250g Caragana korshinskii seeds into the extraction kettle, and set the pressure of the extraction kettle as 25MPa, temperature 50℃, CO 2 The flow rate is 25L / h. Under these conditions, the caragana seeds are extracted and enriched for 110 minutes;

[0059] Step two, pressure reduction separation: set the gradient temperature and pressure reduction program in the first separation kettle, that is, reduce the pressure by 0.208 MPa per minute and 0.083 ℃ per minute within 120 minutes, until the pressure drops to 0 MPa and the temperature drops to 35 ℃, After maintaining for 15 minutes, 16.8 g of the medicinal extract of the seeds of Caragana korshinskii was obtained, with an extraction enrichment rate of 6.72%, and the m...

Embodiment 2

[0063] Example 2 A preparation method of a medicinal extract containing Kagan seeds includes the following steps:

[0064] Step one, extraction and enrichment: open the first valve, the second valve, the third valve, and the fourth valve, and load the dried and crushed 250g Caragana intermedia seeds into the extraction kettle, and set the pressure of the extraction kettle to 35MPa , The temperature is 40℃, CO 2 The flow rate is 40L / h, under these conditions, the caragana seeds are extracted and enriched for 60 minutes;

[0065] Step two, pressure reduction separation: set the gradient temperature and pressure reduction program in the first separation kettle, that is, reduce the pressure by 0.208MPa per minute and 0.083°C per minute within 120 minutes, until the pressure drop is 10MPa and the temperature drops to 30°C, After maintaining for 30 minutes, 15 g of the medicinal extract of the seeds of Caragana korshinskii was obtained, the extraction enrichment rate was 6.00%, and the m...

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Abstract

The invention discloses a method for preparing a medicinal extract containing intermediate peashrub seeds. The method comprises the following steps: performing extraction enrichment, performing reduced pressure separation, dispersing and mixing uniformly; separating and encapsulating, homogenizing and filtering, and collecting to obtain sterile lipidosome of the medicinal extract containing intermediate peashrub seeds. According to the method disclosed by the invention, the oily medicinal extract is extracted and enriched from the intermediate peashrub seeds in a supercritical carbon dioxide environment, and the extract is mixed and encapsulated into drug-containing lipidosome nanoparticles by virtue of a film material. Compared with a traditional medical processing method for rendering the intermediate peashrub seeds or charking co-existence ground powder, the method disclosed by the invention has the advantages that the parameters in the operating process are controllable, the temperature is low, the active ingredients of plants can be well prevented from being damaged, and solvent residue is avoided. Moreover, the drug-containing lipidosome nanoparticles prepared by the invention have the characteristics of targeted drug delivery and long-term release, and because the cell-like structure has cell biocompatibility, drug release can be performed by virtue of a cell membrane. Therefore, the therapeutic index can be improved, and the method is suitable for treatment of skin diseases such as dermatitis, psoriasis, yellow-water sore and skin itch.

Description

Technical field [0001] The invention belongs to the field of dermatological medicines, and in particular relates to a preparation method of a medicinal extract containing karagan seeds. Background technique [0002] Caragana seeds refer to Caragana Korshinskii Kom. and Caragana intermedia Kuang etH.C.Fu of the genus Caragana in the Leguminasae family (Fabaceae). Or the mature seed of Caragana microphylla Lam, which is a traditional medicinal plant resource. The function of Caragana Seed is mainly to relieve itching and insecticide, and can treat neurodermatitis, psoriasis, yellow water sore and impetigo. The traditional way of administration is to boil the caragana seed oil and apply it, or the caragana seed to burn charcoal. Sprinkle on the sore face after grinding. Summary of the invention [0003] The purpose of the present invention is to provide a preparation method of a medicinal extract containing karagan seeds, which aims to solve the traditional preparation method of bo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K36/48A61P17/00A61P17/06A61K131/00
CPCA61K9/0014A61K9/127A61K36/48A61K2236/37
Inventor 王小艳王洪伦索有瑞
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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