Treatment for myelosuppression

A technology of bone marrow suppression and treatment plan, applied in the direction of treatment, radiotherapy, medical preparations containing active ingredients, etc., can solve the problems of life-threatening patients, reduction of treatment dose, side effects of treatment plan, etc.

Active Publication Date: 2018-05-01
CANTEX PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Neutropenia can be caused by a number of different causes, from birth defects to viral infections, but in this context neutropenia is often seen as a side effect of treatment regimens
Neutropenia is a common side effect in patients treated with antineoplastic drugs for cancer, putting patients at risk of serious or even life-threatening infections and delaying treatment and / or necessitating lower treatment doses, resulting in reduced efficacy

Method used

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  • Treatment for myelosuppression
  • Treatment for myelosuppression
  • Treatment for myelosuppression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0243] 6.2 Example 2: ODSH, a heparanoid that interacts with PF4, enhances the efficacy of carboplatin in a mouse xenograft model of human ovarian cancer

[0244] This example demonstrates that adjuvant administration of ODSH enhances the efficacy of carboplatin against human ovarian tumors grown as xenografts in athymic nude mice.

[0245] Materials & Methods ODSH (50 mg / mL stock concentration) was prepared by Pyramid Laboratories, Inc. and stored at room temperature until use. As described further below, ODSH can be administered either intravenously (IV) at a dose of 48 mg / kg and a volume of 10 mL / kg or subcutaneously (SC) at a dose of 24 mg / kg and a volume of 5 mL / kg. Carboplatin obtained from clinical suppliers was stored at 4°C until use. Carboplatin was administered by intraperitoneal injection (IP) at a dose of 80 mg / kg and a volume of 10 mL / kg. Saline solution (0.9% NaCl) was used as a vehicle control for ODSH and was administered by the same route and in the same vo...

Embodiment 3

[0261] 6.3 Example 3: ODSH, a heparanoid that interacts with PF4, alleviates thrombocytopenia and neutropenia, induces thrombopoiesis and neutrophil production and reduces exposure to chemotherapy regimens with myelosuppressive side effects Patient's systemic symptoms

[0262] In an unblinded clinical trial, patients diagnosed with metastatic pancreatic cancer were treated with ODSH as gemcitabine and nab-paclitaxel ( Adjuvant therapy with albumin-bound paclitaxel).

[0263] Inclusion criteria Male and non-pregnant, non-lactating female patients aged 18 to 75 years with histologically confirmed metastatic adenocarcinoma participated in the trial. Other inclusion criteria were: presence of at least one metastatic tumor (measurable by conventional techniques or CT scan), serum CA 19-9 measurement greater than 2 times the upper limit of normal, no local targeted therapy within six months of participation in the trial Radiotherapy or chemotherapy for advanced disease, absolute ...

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Abstract

The present invention provides methods for attenuating the myelosuppressive side effects of a treatment regimen, promoting platelet production and neutrophil production, and increasing the efficacy of a treatment regimen by administering a heparanoid that interacts with PF4.

Description

[0001] 1. Cross references to related applications [0002] This application is based on 35 U.S.C. § 119(e) requiring U.S. provisional applications 61 / 724,836 (filed November 9, 2012); 61 / 702,207 (filed September 17, 2012); 61 / 678,053 (filed 2012 61 / 668,709 (filed 6 July 2012); 61 / 664,611 (filed 26 June 2012); 61 / 653,362 (filed 30 May 2012); 61 / 648,043 (filed May 16, 2012); 61 / 644,623 (filed May 9, 2012); and 61 / 644,556 (filed May 9, 2012), the entire contents of which are incorporated herein as refer to. 2. Background technology [0003] Platelets play a key role in the coagulation mechanism. Thrombocytopenia below a certain level results in thrombocytopenia, which can be triggered by a range of clinical conditions or disorders and can extend from mild to life-threatening. [0004] Thrombocytopenia can be triggered by diseases or conditions affecting the bone marrow, in which platelet precursors appear before entering the bloodstream; by diseases or conditions affecting ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/727A61K31/715C08B37/10
CPCA61K31/727A61K45/06A61P35/02A61P7/00A61P7/04A61K35/28A61K39/395A61N5/00
Inventor S.马库斯
Owner CANTEX PHARMA
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