Process for extracting high-content liquid gingerol

An extraction process, gingerol technology, applied in the field of plant extracts and its preparation, can solve the problems of heavy metal residues in product changes, low separation efficiency, high production costs, etc., to achieve better product quality, good repeatability, and quality Guaranteed effect

Inactive Publication Date: 2015-03-25
QINGDAO ZHONGREN ZHIYE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] So far, the methods for preparing high-content gingerol mainly include solvent extraction and separation-multiple solvent extraction, supercritical extraction combined with column chromatography, etc. These methods In the process of separation and purification, high temperature is required,

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  • Process for extracting high-content liquid gingerol

Examples

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Effect test

Example Embodiment

[0034] Example 1

[0035] The method for preparing high-content liquid gingerol in this embodiment includes the following steps:

[0036] (1) Using 0.5 kg of ginger resin, the content of gingerol is 38.2%, the conditions of supercritical carbon dioxide extraction are: extraction pressure / temperature 30MPA / 40℃, primary separation pressure / temperature 12MPA / 45℃, secondary separation pressure / Temperature 5MPA / 35℃. The ginger resin is obtained in the primary separator, and volatile components are mainly contained in the secondary separator. Add 2.25 kg of 70% ethanol aqueous solution to the ginger resin, stir, filter to remove a small amount of insoluble matter, and obtain a clear ginger resin alcohol solution;

[0037] (2) Such as figure 1 As shown, the above-mentioned alcoholic solution of ginger resin is transferred to a glass liquid-liquid extractor (diameter 90 mm × height 1100 mm), and then petroleum ether (boiling range 60 ~ 90 ℃) is passed through the bottom of the extracto...

Example Embodiment

[0041] Example 2

[0042] The method for preparing high-content liquid gingerol in this embodiment includes the following steps:

[0043] (1) Using 1.0 kg of ginger resin, the content of gingerol is 39.4%, the conditions of supercritical carbon dioxide extraction are: extraction pressure / temperature 30MPA / 45℃, primary separation pressure / temperature 13MPA / 45℃, secondary separation pressure / Temperature 5MPA / 35℃. The ginger resin is obtained in the primary separator, and volatile components are mainly contained in the secondary separator. Add 4.0 kg of a 75% ethanol aqueous solution by weight to it, stir, filter to remove a small amount of insoluble matter, and obtain a clear ginger resin alcohol solution;

[0044] (2) Transfer the above-mentioned alcohol solution of ginger resin to a glass liquid-liquid extractor (diameter 90 mm × height 1100 mm), and then use a metering pump 8 to transfer petroleum ether (boiling range 60~90℃) through the bottom of the extractor The distributor...

Example Embodiment

[0047] Example 3

[0048] The method for preparing high-content liquid gingerol in this embodiment includes the following steps:

[0049] (1) Using 2.0 kg of ginger resin, its gingerol content is 37.1%, and the conditions for supercritical carbon dioxide extraction are: extraction pressure / temperature 32MPA / 45℃, primary separation pressure / temperature 14MPA / 50℃, secondary separation pressure / Temperature 5MPA / 35℃. The ginger resin is obtained in the primary separator, and volatile components are mainly contained in the secondary separator. Add 7.5 kg of 80% ethanol aqueous solution by weight to it, stir, filter to remove a small amount of insoluble matter, and obtain a clear ginger resin alcohol solution;

[0050] (2) Transfer the above-mentioned alcohol solution of ginger resin to a glass liquid-liquid extractor (diameter 110 mm × height 1300 mm), and then use a metering pump 8 to transfer petroleum ether (boiling range 60 to 90°C) through the bottom of the extractor The distrib...

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Abstract

The invention discloses a process for extracting high-content liquid gingerol. The process comprises the following steps: by virtue of the characteristic that the solubility degrees of different components in natural and high-quality ginger oleoresin which is extracted by using supercritical carbon dioxide are greatly different in ethanol and petroleum ether of a certain concentration, continuously extracting fat soluble impurity components in ethanol phase by using petroleum ether, further extracting by using diethyl ether, separating and purifying, thereby obtaining high-content liquid gingerol. The high-content liquid gingerol is a light brown red liquid with relatively poor flowability, is quietly elegant and pure in fragrance and long-lasting in base fragrance, the content of gingerol is greater than 90%, and the residual amounts of heavy metals such as arsenic, cadmium, lead and mercury are all less than 0.1ppm.

Description

technical field [0001] The invention relates to a plant extract and a preparation method thereof, in particular to a high-content gingerol and a preparation method thereof. Background technique [0002] Ginger is a medicinal and edible plant that is closely related to people's life and health. Regardless of ancient or modern times, or at home and abroad, ginger and its products have never left people's lives. Studies have shown that the main active ingredients of raw (dry) ginger are volatile oil and gingerol. Gingerol is a general term for a variety of substances with similar structures in raw (dried) ginger, all of which contain 3-methoxy-4-hydroxyphenyl functional groups, mainly including gingerols (Gingerols) , Shogals, Paradols, Zingerones, Gingerdiones, Gingerdiols, and gingerol is its main component. [0003] Modern pharmacological research has found that gingerol is the main active ingredient in the pharmacological effects of ginger and its preventive and health ca...

Claims

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Application Information

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IPC IPC(8): C07C49/255C07C45/78
CPCC07C45/78C07C49/255Y02P20/54
Inventor 侯维
Owner QINGDAO ZHONGREN ZHIYE BIOTECH
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